| Cat. No. |
Product Name |
Information |
| PC-20398 |
Rynaxypyr
RyR activator
|
Rynaxypyr (Chlorantraniliprole) is a highly potent and selective activator of insect ryanodine receptors (Hv RyR EC50=52 nM) with exceptional activity on a broad range of Lepidoptera. |
| PC-20397 |
RyR2 inhibitor EL9
RyR2 inhibitor
|
RyR2 inhibitor EL9 is a potent mutant RyR2 channel inhibitor, inhibits Ca2+ spark frequency (CaSF) in R176Q/+ myocytes with IC50 of 13 nM. |
| PC-20396 |
RyR2 inhibitor EL20
RyR2 inhibitor
|
RyR2 inhibitor EL20 is a potent antiarrhythmic compound, potently inhibits abnormal Ca2+ release in RyR2 R176Q myocytes with IC50 of 35.4 nM. |
| PC-20395 |
Cyantraniliprole
RyR activator
|
Cyantraniliprole (DPX-HGW86) is an insecticide of the ryanoid class, is a potent and selective anthranilic diamide ryanodine receptor (RyR) activator (Dipteran RyR, EC50=0.9 uM). |
| PC-20121 |
IPPQ
CaV2.2 inhibitor
|
IPPQ is a small molecule that selectively target the interface between the N-type calcium (CaV2.2) channel and CaVβ, specifically binds to CaVβ2a and inhibits CaVβ2's interaction with CaV.2-AID (alpha interacting domain). |
| PC-49748 |
HSK16149
VGCC α2δ ligand
|
HSK16149 (HSK 16149) is a potent selective ligand of voltage-gated calcium channel (VGCC) α2δ subunit with IC50 of 3.96 nM in competitive [3H]gabapentin binding assays. |
| PC-47015 |
2E151
Calcium channel activator
|
2E151 is a small molecule calcium channel activator, increases murine antigen-specific antibody responses when used as a co-adjuvant with LPS. |
| PC-47014 |
2D216
Calcium channel activator
|
2D216 is a small molecule calcium channel activator, increases murine antigen-specific antibody responses when used as a co-adjuvant with LPS. |
| PC-38654 |
CRAC inhibitor 36
CRAC channel inhibitor
|
CRAC inhibitor 36 is a novel potent, selective calcium release-activated calcium (CRAC) channels inhibitor with IC50 of 11 nM (IL-2 inhibition) and 243 nM (SOCE inhibition). |
| PC-38485 |
VK-II-86
RyR2 inhibitor
|
VK-II-86 is a carvedilol analogue lacking antagonist activity at β-adrenoceptors, effectively suppresses SOICR by directly reducing the open duration of the cardiac ryanodine receptor (RyR2). |
| PC-38452 |
VK-II-36
RyR2 inhibitor
|
VK-II-36 is a carvedilol analogue that suppresses sarcoplasmic reticulum (SR) Ca(2+) release and does not block the β-receptor, via direct action on the cardiac ryanodine receptor type 2 (RyR2). |
| PC-38432 |
Zegocractin
Orai1 channel inhibitor
|
Zegocractin (CM4620) is a selective small molecule CRAC (Orai1) channel inhibitor, inhibits Orai1/STIM1-mediated Ca2+ currents and Orai2/STIM1-mediated currents with IC50 of 120 nM and 900 nM, respectively. |
