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Cat. No. Product Name Information
PC-20398

Rynaxypyr

RyR activator

Rynaxypyr (Chlorantraniliprole) is a highly potent and selective activator of insect ryanodine receptors (Hv RyR EC50=52 nM) with exceptional activity on a broad range of Lepidoptera.
PC-20397

RyR2 inhibitor EL9

RyR2 inhibitor

RyR2 inhibitor EL9 is a potent mutant RyR2 channel inhibitor, inhibits Ca2+ spark frequency (CaSF) in R176Q/+ myocytes with IC50 of 13 nM.
PC-20396

RyR2 inhibitor EL20

RyR2 inhibitor

RyR2 inhibitor EL20 is a potent antiarrhythmic compound, potently inhibits abnormal Ca2+ release in RyR2 R176Q myocytes with IC50 of 35.4 nM.
PC-20395

Cyantraniliprole

RyR activator

Cyantraniliprole (DPX-HGW86) is an insecticide of the ryanoid class, is a potent and selective anthranilic diamide ryanodine receptor (RyR) activator (Dipteran RyR, EC50=0.9 uM).
PC-20121

IPPQ

CaV2.2 inhibitor

IPPQ is a small molecule that selectively target the interface between the N-type calcium (CaV2.2) channel and CaVβ, specifically binds to CaVβ2a and inhibits CaVβ2's interaction with CaV.2-AID (alpha interacting domain).
PC-49748

HSK16149

VGCC α2δ ligand

HSK16149 (HSK 16149) is a potent selective ligand of voltage-gated calcium channel (VGCC) α2δ subunit with IC50 of 3.96 nM in competitive [3H]gabapentin binding assays.
PC-49733

PST3093

SERCA2a activator

PST3093 (PST 3093) is the main Istaroxime metabolite and a selective SERCA2a activator, reduces the SERCA2a KdCa value by about 20% at 100 nM.
PC-49732

Istaroxime hydrochloride

Na-K ATPase inhibitor

Istaroxime (PST2744) is an inotropic agent and Na(+)/K(+)-ATPase inhibitor, inhibits dog kidney Na(+)/K(+)-ATPase with IC50 of 0.43 uM, also stimulates SERCA2a.
PC-47015

2E151

Calcium channel activator

2E151 is a small molecule calcium channel activator, increases murine antigen-specific antibody responses when used as a co-adjuvant with LPS.
PC-47014

2D216

Calcium channel activator

2D216 is a small molecule calcium channel activator, increases murine antigen-specific antibody responses when used as a co-adjuvant with LPS.
PC-38654

CRAC inhibitor 36

CRAC channel inhibitor

CRAC inhibitor 36 is a novel potent, selective calcium release-activated calcium (CRAC) channels inhibitor with IC50 of 11 nM (IL-2 inhibition) and 243 nM (SOCE inhibition).
PC-38485

VK-II-86

RyR2 inhibitor

VK-II-86 is a carvedilol analogue lacking antagonist activity at β-adrenoceptors, effectively suppresses SOICR by directly reducing the open duration of the cardiac ryanodine receptor (RyR2).

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