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Cat. No. Product Name Information
PC-49284

BML-277

Chk2 inhibitor

BML-277 (BML277) is a potent, selective and ATP-competitive inhibitor of Chk2 serine/threonine kinase with IC50 of 15 nM, >1000-fold selectivity over Chk1 and Cdk1/B kinases.
PC-35602

PF-00477736

CHK1 inhibitor

PF-00477736 (PF-477736) is a potent, selective, ATP-competitive inhibitor of Chk1 with Ki of 0.49 nM, also inhibits Chk2 (Ki=47 nM) and poorly inhibits CDK1 activity (Ki=9.9 uM).
PC-35362

BAY-524

BUB1 inhibitor

BAY-524 (BAY524) is a potent, selective, ATP-competitive inhibitor of Bub1 kinase with IC50 of 450 nM.
PC-43443

CHIR-124

CHK1 inhibitor

CHIR-124 is a potent, selective Chk1 inhibitor with in vitro IC50 of 0.3 nM, 2,000-fold selectivity over Chk2.
PC-63128

BAY-1816032

BUB1 inhibitor

BAY-1816032 (BAY1816032) is a highly potent, selective, orally active BUB1 mitotic checkpoint serine/threonine kinase with IC50 of 7 nM, displays excellent selectivity on a panel of 395 kinases.
PC-63043

SAR-020106

CHK1 inhibitor

SAR-020106 (SAR-20106) is a potent and selective CHK1 inhibitor with IC50 of 13 nM, with high selectivity over CHK2 (IC50>100 uM).
PC-62476

MK 8776

CHK1 inhibitor

MK 8776 (SCH 900776) is a potent and functionally selective CHK1 inhibitor (IC50=3 nM) with minimal intrinsic antagonistic properties.
PC-62037

MARPIN

CHK1 inhibitor

MARPIN is a novel ATR-Chk1 pathway inhibitor that inhibits hydroxyurea (HU)-induced phosphorylation of Ser345 on Chk1 with IC50 of 7.7 uM.
PC-60583

MU 380

CHK1 inhibitor

MU 380 is a novel potent, selective CHK1 inhibitor with IC50 of 2 nM, >80-fold selectivity over CHK2.
PC-60310

GNE-900

CHK1 inhibitor

GNE-900 (GNE900) is a potent, selective, ATP-competitive, and orally bioavailable Chk1 inhibitor with IC50 of <1 nM.
PC-60291

Debromohymenialdisine

Chk1/Chk2 inhibitor

Debromohymenialdisine (SKF108753) is a marine sponge alkaloid that inhibits Chk1 and Chk2 with IC50 of 3 and 3.5 uM, respectively.
PC-60290

SB-218078

CHK1 inhibitor

SB-218078 (SB218078) is a potent inhibitor of Chk1 that blocks phosphorylation of cdc25 with IC50 of 15 nM.

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