You are here:Home-Chemical Inhibitors & Agonists-Immunology/Inflammation-Complement System

Request The Product List ofComplement System Complement System

Cat. No. Product Name Information
PC-21586

C1s inhibitor A1

C1s inhibitor

C1s inhibitor A1 is a selective, competitive inhibitor of complement component C1s with binding Kd of 9.8 uM, competitively inhibits its activity with Ki of 5.8 uM.
PC-20806

NSC33353

C5a receptor inhibitor

NSC33353 (NSC 33353) is a small molecule inhibitor with potent anti-tumor activity against TNBC cells, enhances TNBC sensitivity to doxorubicin, also is an inhibitor of C5a receptor binding.
PC-20173

Sepimostat

Multi-protease inhibitor

Sepimostat (FUT-187) is a potent multi-protease inhibitor with IC50 of 0.097 uM for trypsin, 0.029 uM for pancreatic kallikrein, 0.61 uM for plasma kallikrein, 0.57uM for plasmin, 2.5 uM for thrombin, 20.4 uM for factor Xa and 6.4 uM for C1r.
PC-38846

W54011

C5aR inhibitor

W-54011 (W54011) is a potent, selective, orally active and non-peptide C5a receptor antagonist, inhibits the binding of 125I-labeled C5a to human neutrophils with Ki of 2.2 nM.
PC-38845

PMX205

C5aR inhibitor

PMX205 is a potent, selective C5a receptor peptide antagonist with IC50 of 30 nM.
PC-38358

Vemircopan

Factor D inhibitor

Vemircopan (ALXN2050, ACH 5228) is a second generation, orally active complement factor D inhibitor, has the potential to decrease disease symptoms and increase strength in generalized myasthenia gravis (gMG).
PC-38352

JYN42346

Factor D inhibitor

JYN42346 (Complement factor D-IN-2) is an inhibitor of complement factor D, inhibits the complement cascade at an early and essential point in the alternative complement pathway.
PC-73000

C5 complement inhibitor 7

C5 complement inhibitor

C5 complement inhibitor 7 (C5-IN-7) is a potent, small-molecule inhibitor of C5 complement protein with serum assay IC50 of <5 nM (2% human serum complement inhibition).
PC-72455

AMY-101

C3 inhibitor

AMY-101 (Cp40) is a peptidic inhibitor of the central complement component C3 for the management of patients with ARDS caused by SARS-CoV-2 infection.
PC-72006

C3aR antagonist JR14a

C3aR antagonist

C3aR antagonist JR14a is a potent and selective antagonist of human Complement C3a receptor (hC3aR) with IC50 of 10 nM (Inhibition of intracellular Ca2+ release induced by 100 nM C3a).
PC-72001

JPE1375

C5aR inhibitor

JPE1375 is a potent, peptidomimetic C5a receptor antagonist with IC50 of 39 nM, inhibits neutrophil influx in the RPAR in mice.
PC-72000

BM213

C5aR1 agonist

BM213 (BM-213) is a potent, selective and stable peptide C5aR1 agonist with EC50 of 59 nM.

Request The Product List

* Indicates a Required FieldYour information is safe with us.

  • *Product List:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Country:
  • Additional Information:

Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright

Contact Us sales@probechem.com