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Cat. No. Product Name Information
PC-21140

Cyclin K degrader DS17

cyclin K degarder

Cyclin K degrader DS17 is a selective cyclin K molecular glue degrader with TR-FRET EC50 of 19 nM.
PC-21051

SW394703

cyclin K degrader

SW394703 is a novel DDB1-dependent molecular glue degrader for cyclin K, SW394703 is toxic to HCT116 cells (IC50=1.2 uM).
PC-20316

LDC4297

CDK7 inhibitor

LDC4297 (LDC044297) is a potent, highly specific CDK7 inhibitor with IC50 of 7.4 nM in ATP competition assays (3.5 mM ATP), weakly inhibits CDK2 (IC50>2 uM).
PC-20219

CDK8 inhibitor 32

CDK8 inhibitor

CDK8 inhibitor 32 is a potent selective CDK8 inhibitor with IC50 of 1.5 nM, reduces phosphorylation of the known CDK8 substrate STAT1 in a manner identical to a CDK8 knockout clone.
PC-49789

RGB-286147

CDK inhibitor

RGB-286147 (RGB 286147) is a proteome-wide CDK/CRK-specific kinase inhibitor with IC50 of 48 and 15 nM for CDK1/CycB and CDK2/CycE, respectively.
PC-49785

ISM042-2-048

CDK20 inhibitor

ISM042-2-048 is a potent, selective inhibitor of cyclin-dependent kinase 20 (CDK20, cell cycle-related kinase/CCRK) with IC50 of 33.4 nM (CDK20/CycT1), Kd value of 566 nM.
PC-49575

PF-07220060

CDK4 inhibitor

PF-07220060 (CDK4/6-IN-6) is a potent and selective, orally active CDK4 inhibitor with Ki of 0.6 nM (CDK4/Cyclin D1), significant sparing of CDK6 (Ki=13.9 nM CDK6/Cyclin D3).
PC-49485

KB-0742 dihydrochloride

CDK9 inhibitor

KB-0742 (KB0742) is a potent, orally bioavailable, selective CDK9 inhibitor with IC50 of 6 nM (CDK9/cyclin T1 inhibition).
PC-49444

MK256

CDK8/19 inhibitor

MK256 (MK-256) is a potent, selective CDK8 inhibitor with IC50 of 2.5 nM and 3.3 nM against CDK8/cyclin C and CDK19/cyclin C, respectively.
PC-49260

ZSQ836

CDK12/13 inhibitor

ZSQ836 (ZSQ 836) is a potent, selective and orally bioavailable CDK12/CDK13 covalent inhibitor with IC50 of 32 nM (CDK12), covalently interacts with Cys1039 of CDK12.
PC-49204

SNX631

CDK8/19 inhibitor

SNX631 (SNX-631) is a potent, selective inhibitor of CDK8/19 Mediator kinase with IC50 of 10.3 nM in the NF κB-dependent cell-based assays.
PC-49131

Culmerciclib

CDK4/6 inhibitor

TQB3616 (Culmerciclib) is a potent, selective inhibitor of CDK4/6 with IC50 of 0.35 nM and 0.49 nM for CDK4/D1CDK6/D1 respectively, shows remarkable inhibitory effect on hormone receptor-positive breast cancer cells.

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