| Cat. No. |
Product Name |
Information |
| PC-27703 |
UOM-005636
Cyclin K degrader
|
UOM-005636 is a molecular glue degrader (MGD) that mediates the CRL4-dependent proteolysis of cyclin K with IC50 of 85 nM in OCI-AML5 cells, mediates cyclin K degradation through DDB1 bridging the CRL4 complex. |
| PC-27702 |
Cyclin K MGD S656
Cyclin K degrader
|
Cyclin K MGD S656 is a molecular glue degrader (MGD) that mediates the CRL4-dependent proteolysis of cyclin K with IC50 of 743 nM in OCI-AML5 cells, mediates cyclin K degradation through the cullin RING ubiquitin ligase complex. |
| PC-27634 |
ZJC-11
CDK7 inhibitor
|
ZJC-11 is a potent, selective and covalent cyclin-dependent kinase 7 (CDK7) inhibitor with IC50 of 5.4 nM, has >100-fold selectivity over CDK1/2/9. |
| PC-27510 |
Tudociclib
CDK2 inhibitor
|
Tudociclib (INCB123667) is a potent and selective, orally available small molecule inhibitor of CDK2 with IC50 of <20 nM, is inactive against CDK1, CDK4, CDK6, CDK7, and CDK9. |
| PC-26877 |
CDK17 inhibitor DU12
CDK17 inhibitor
|
DU12 is a potent small molecule CDK17 inhibitor with IC50 of 0.76 uM against recombinant CDK17 kinase, inhibits the proliferation, colony formation, migration, and invasion of SKOV3 and A2780 ovarian cancer cells with IC50 of 2.83 uM and 2.65 uM. |
| PC-26764 |
A09-003
CDK9 inhibitor
|
A09-003 is a potent inhibitor of cyclin-dependent kinase-9 (CDK9) with IC50 of 16 nM. |
| PC-26376 |
CTX-439
CDK12 inhibitor
|
CTX-439 is a potent, selective, orally bioavailable, ATP-competitive CDK12/13 inhibitor with IC50 of 3.1/ 9.2 nM towards CDK12/Cyclin K and CDK13/Cyclin K, respectively, in cell-free assays. |
| PC-25971 |
LL-K12-18
Cyclin K degrader
|
LL-K12-18 is a potent, dual-site molecular glue degrader of cyclin K with DC50 of 0.38 nM in MDA-MB-231 cells, inhibits CDK12 with IC50 of 283.9 nM. |
| PC-25402 |
TP-1287
CDK9 inhibitor
|
TP-1287 is a prodrug of Alvocidib (Flavopiridol, HMR-1275), is an orally active CDK9 inhibitor. |
| PC-25358 |
CIRc-004
Cyclin A/B RxL inhibitor
|
CIRc-004 is a potent, cell-permeable dual cyclin A/B RxL inhibitor with IC50 of 0.13 and <0.02 uM for cyclin A1-CDK2 and cyclin B-CDK1, does not inhibit cyclin E1-CDK2, inhibits cyclin A/B-RxL interactions and induces apoptosis in cancer cells with high E2F activity. |
| PC-24989 |
AU3-14
CDK4/6 inhibitor
|
Auceliciclib (AU3-14, Ulecaciclib AU-314) is a potent and selective, brain-penetrant CDK4/6 inhibitor with Ki values ranging from 0.2 to 3.3 nM. |
| PC-24960 |
Mocaciclib
CDK7 inhibitor
|
Mocaciclib (Q901) is a highly selective and potent CDK7 inhibitor, forms a covalent bond with C312 of the CDK7 C-terminal domain. |
