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Cat. No. Product Name Information
PC-49682

NSC232003

UHRF1 inhibitor

NSC232003 is a small molecule inhibitor of ubiquitin-like protein UHRF1, bind the 5-methylcytosine pocket of UHRF1 and inhibit its functionality, reduces DNMT1/UHRF1 interactions in U251 glioma cells with IC50 of 15 uM, induces global DNA cytosine demethylation.
PC-49681

UF146

UHRF1 inhibitor

UF146 (UF-146) is a specific small molecule inhibitor of ubiquitin-like protein UHRF1, binds with the SRA domain groove of UHRF1 with KD of 3.71 uM, significantly inhibits the binding of UHRF1 and hemi-methylated DNA with IC50 of 499.4 nM in FRET assays.
PC-73377

GSK3543105

DNMT1 inhibitor

GSK3543105 is a potent, selective, non-nucleoside inhibitor of DNMT1 with IC50 of 33 nM.
PC-72249

5A-DMP

UHRF1 inhibitor

5A-DMP is a novel TTD-binding compound that binds to tandem Tudor domain (TTD) of UHRF1, inhibits the full-length UHRF1: LIG1 interaction in Xenopus egg extracts.
PC-72246

GSK3482364

DNMT1 inhibitor

GSK3482364 (GSK348236428) is a selective, reversible, orally active inhibitor of DNMT1 with IC50 of 0.4 uM, >375-fold selectivity over DNMT3A/3L and DNMT3B/3L (IC50>150 uM).
PC-72245

GSK3484862

DNMT1 inhibitor

GSK3484862 (GSK-3484862) is a selective, non-covalent inhibitor of DNMT1, potently inhibits DNMT1 enzymatic activity with IC50 of 0.23 uM.
PC-72244

GSK3685032

DNMT1 inhibitor

GSK3685032 (GSK-3685032) is a potent, first-in-class, highly selective DNMT1 inhibitor with IC50 of 36 nM, >2,500-fold over DNMT3A/3L and DNMT3B/3L.
PC-38285

STM2457

METTL3/METTL14 inhibitor

STM2457 (STM-2457) is a highly potent, selective first-in-class catalytic inhibitor of METTL3 with IC50 of 16.9 nM, binds to the METTL3-METTL14 with Kd of 1.4 nM.
PC-36114

Bobcat339

TET inhibitor

Bobcat339 (Bobcat 339) is a novel cytosine-based TET enzyme inhibitor with IC50 of 33 uM (TET1) and 73 uM (TET2), but not DNMT3a, does not inhibit the DNA methyltransferase DNMT3a.
PC-35290

MC3343

DNMT inhibitor

MC3343 (MC-3343) is a novel potent, non-nucleoside DNA methyltransferase (DNMT) inhibitor with IC50 of 5.7 and 1.7 uM for DNMT1 and DNMT3a in cell-free assays, respectively.
PC-35122

NV03

UHRF1 inhibitor

NV03 is a small-molecule antagonist of the H3K9me3 binding to UHRF1 tandem tudor domain with Kd of 2.4 uM.
PC-35121

NV01

UHRF1 inhibitor

NV01 is a small-molecule antagonist of the H3K9me3 binding to UHRF1 tandem tudor domain (TTD) with Kd of 5 uM.

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