| Cat. No. |
Product Name |
Information |
| PC-49681 |
UF146
|
UF146 (UF-146) is a specific small molecule inhibitor of ubiquitin-like protein UHRF1, binds with the SRA domain groove of UHRF1 with KD of 3.71 uM, significantly inhibits the binding of UHRF1 and hemi-methylated DNA with IC50 of 499.4 nM in FRET assays. |
| PC-73377 |
GSK3543105
|
GSK3543105 is a potent, selective, non-nucleoside inhibitor of DNMT1 with IC50 of 33 nM. |
| PC-72246 |
GSK3482364
|
GSK3482364 (GSK348236428) is a selective, reversible, orally active inhibitor of DNMT1 with IC50 of 0.4 uM, >375-fold selectivity over DNMT3A/3L and DNMT3B/3L (IC50>150 uM). |
| PC-72244 |
GSK3685032
|
GSK3685032 (GSK-3685032) is a potent, first-in-class, highly selective DNMT1 inhibitor with IC50 of 36 nM, >2,500-fold over DNMT3A/3L and DNMT3B/3L. |
| PC-38285 |
STM2457
|
STM2457 (STM-2457) is a highly potent, selective first-in-class catalytic inhibitor of METTL3 with IC50 of 16.9 nM, binds to the METTL3-METTL14 with Kd of 1.4 nM. |
| PC-36114 |
Bobcat339
|
Bobcat339 (Bobcat 339) is a novel cytosine-based TET enzyme inhibitor with IC50 of 33 uM (TET1) and 73 uM (TET2), but not DNMT3a, does not inhibit the DNA methyltransferase DNMT3a. |
| PC-35290 |
MC3343
|
MC3343 (MC-3343) is a novel potent, non-nucleoside DNA methyltransferase (DNMT) inhibitor with IC50 of 5.7 and 1.7 uM for DNMT1 and DNMT3a in cell-free assays, respectively. |
