| Cat. No. |
Product Name |
Information |
| PC-73106 |
AZD7648
|
AZD7648 (AZD-7648) is a potent, selective inhibitor of DNA-PK catalytic subunit (DNA-PKcs) with IC50 of 0.6 nM. |
| PC-63031 |
KU-0060648
|
KU-006064 is a potent, dual inhibitor of DNA-PK (IC50=8.6 nM) and PI3K (IC50=4/0.5/0.1 nM for PI3Kα/β/δ). |
| PC-61389 |
M3814
|
M3814 (Nedisertib, Peposertib, MSC2490484A) is a highly potent, selective, ATP-competitive and orally bioavailable inhibitor of DNA-PK with IC50 of 0.6 nM (10 uM ATP). |
| PC-42782 |
NU-7441
|
NU-7441 (KU 57788) is a highly potent and selective DNA-PK inhibitor (IC50=14 nM). |
| PC-20221 |
SN38023
|
SN38023 is a bioreductive prodrug of DNA-dependent protein kinase inhibitor IC87361 (Cat# PC-62995), SN38023 is metabolised to a potent DNA-PKi (IC87361) selectively in radioresistant hypoxic cells. |
| PC-20171 |
Ku-DBi 245
|
Ku-DBi 245 is a novel DNA-PK inhibitor with a unique mechanism of action, blocking the Ku 70/80 heterodimer interaction with DNA. |
| PC-72056 |
BAY-8400
|
BAY-8400 (BAY8400) is a highly potent, selective inhibitor of DNA-PK with biochemical IC50 of 81 nM, cellular IC50 of 69 nM (γH2AX in HT-144). |
