| Cat. No. |
Product Name |
Information |
| PC-23528 |
iBFAR2
BFAR inhibitor
|
iBFAR2 is a specific small molecule inhibitor of ubiquitin E3 ligase bifunctional apoptosis regulator (BFAR), inhibits USP39 ubiquitination and JAK2 deubiquitination, promoting STAT1 phosphorylation and tissue resident memory T cells (TRM) differentiation, boosts antitumor immunity in aged mice. |
| PC-21767 |
AAA-237
Skp2 inhibitor
|
AAA-237 (SCFSkp2-IN-2) is a small molecule Skp2 E3 ligase inhibitor, binds to Skp2 protein (KD=28.77 uM) and inhibits the degradation of Skp2 substrates, inhibits the proliferation of the NSCLC cells. |
| PC-21766 |
Smurf1 inhibitor A01
Smurf1 inhibitor
|
Smurf1 inhibitor A01 is a specific small molecule inhibitor of ubiquitin ligase Smad ubiquitination regulatory factor-1 (Smurf1) with Kd of 3.66 nM for interrupting Smurf1-Smad1 interaction, impairs Smurf1-mediated Smad1/5 degradation and stabilizes Smad1/5 protein level. |
| PC-21554 |
Nx-1607
Cbl-b inhibitor
|
Nx-1607 (Nx1607) is a small-molecule inhibitor of the RING-type E3 ubiquitin ligase Cbl-b with IC50 of 0.46 nM. |
| PC-21396 |
SMIP004
Skp2 inhibitor
|
SMIP004 is a small molecule inducer of cancer-cell selective apoptosis and S-phase kinase-associated protein 2 (Skp2) inhibitor, shows anti-cancer and antidepressant-like activities. |
| PC-21374 |
Nimbolide
RNF114 inhibitor
|
Nimbolide is a natural product derived from the Neem tree, inhibits E3 ligase activity of RNF114, blocks PARP1 degradation and causes PARP1 trapping. |
| PC-21056 |
Skp2-2
Skp2-Cks1 inhibitor
|
Skp2-2 is a small molecule inhibitor of Skp2-Cks1 interaction with IC50 of 27.8 uM, significantly and dose-dependently reduces the protein expression of Skp2 in cancer cells. |
| PC-20550 |
T0467
PINK1-Parkin activator
|
T0467 is a small molecule activator of PINK1-Parkin signaling, activates Parkin mitochondrial translocation in dopaminergic neurons and myoblasts (20 uM, 3h), does not induce mitochondrial accumulation of PINK1. |
| PC-20317 |
BC1464
FBXO7 inhibitor
|
BC1464 (BC 1464) is a small molecule inhibitor of ubiquitin E3 ligase receptor component FBXO7, efficiently decreases the interaction between FBXO7 and PINK1, increases cellular PINK1 concentrations and activities. |
| PC-20292 |
OICR-8268
DCAF1 ligand
|
OICR-8268 (OICR8268) is a highly potent, reversible, small molecule ligand of DCAF1 (Vpr binding protein) with SPR KD of 38 nM, a substrate receptor of two distinct E3 ligases (CRL4DCAF1 and EDVP). |
| PC-20113 |
PELI1-EGFR inhibitor S62
PELI1/EGFR inhibitor
|
PELI1-EGFR inhibitor S62 is a small molecule inhibitor of the interaction between PELI1 and EGFR, suppresses breast cancer metastasis. |
| PC-49510 |
NAB2
Nedd4 inhibitor
|
NAB2 (Nedd4 inhibitor NAB2) is a specific small molecule inhibitor of E3 ubiquitin ligase Nedd4 with binding KD of 42 nM. |
