| Cat. No. |
Product Name |
Information |
| PC-23528 |
iBFAR2
BFAR inhibitor
|
iBFAR2 is a specific small molecule inhibitor of ubiquitin E3 ligase bifunctional apoptosis regulator (BFAR), inhibits USP39 ubiquitination and JAK2 deubiquitination, promoting STAT1 phosphorylation and tissue resident memory T cells (TRM) differentiation, boosts antitumor immunity in aged mice. |
| PC-21766 |
Smurf1 inhibitor A01
Smurf1 inhibitor
|
Smurf1 inhibitor A01 is a specific small molecule inhibitor of ubiquitin ligase Smad ubiquitination regulatory factor-1 (Smurf1) with Kd of 3.66 nM for interrupting Smurf1-Smad1 interaction, impairs Smurf1-mediated Smad1/5 degradation and stabilizes Smad1/5 protein level. |
| PC-21554 |
Nx-1607
Cbl-b inhibitor
|
Nx-1607 (Nx1607) is a small-molecule inhibitor of the RING-type E3 ubiquitin ligase Cbl-b with IC50 of 0.46 nM. |
| PC-21374 |
Nimbolide
RNF114 inhibitor
|
Nimbolide is a natural product derived from the Neem tree, inhibits E3 ligase activity of RNF114, blocks PARP1 degradation and causes PARP1 trapping. |
| PC-20317 |
BC1464
FBXO7 inhibitor
|
BC1464 (BC 1464) is a small molecule inhibitor of ubiquitin E3 ligase receptor component FBXO7, efficiently decreases the interaction between FBXO7 and PINK1, increases cellular PINK1 concentrations and activities. |
| PC-20292 |
OICR-8268
DCAF1 ligand
|
OICR-8268 (OICR8268) is a highly potent, reversible, small molecule ligand of DCAF1 (Vpr binding protein) with SPR KD of 38 nM, a substrate receptor of two distinct E3 ligases (CRL4DCAF1 and EDVP). |
| PC-20113 |
PELI1-EGFR inhibitor S62
PELI1/EGFR inhibitor
|
PELI1-EGFR inhibitor S62 is a small molecule inhibitor of the interaction between PELI1 and EGFR, suppresses breast cancer metastasis. |
| PC-49510 |
NAB2
Nedd4 inhibitor
|
NAB2 (Nedd4 inhibitor NAB2) is a specific small molecule inhibitor of E3 ubiquitin ligase Nedd4 with binding KD of 42 nM. |
| PC-49453 |
Thiolutin
HOIP inhibitor
|
Thiolutin (Acetopyrrothin) is a small molecule inhibitor of the catalytic activity of E3 ubiquitin ligase HOIP, a catalytic subunit of linear ubiquitin chain assembly complex (LUBAC). |
| PC-49196 |
BC18630 free base
DCAF7 inhibitor
|
BC18630 free base (BC 18630) is a small molecule inhibitor of the E3 ubiquitin ligase subunit DCAF7, potently inhibits SARS-CoV-2 infection with IC50 of 39 nM in cell-based assays. |
| PC-49194 |
BC18813
DCAF7 inhibitor
|
BC18813 (BC 18813) is a small molecule inhibitor of the E3 ubiquitin ligase subunit DCAF7, potently inhibits SARS-CoV-2 infection with IC50 of 48 nM in cell-based assays. |
| PC-49193 |
BC18630
DCAF7 inhibitor
|
BC18630 (BC 18630) is a small molecule inhibitor of the E3 ubiquitin ligase subunit DCAF7, potently inhibits SARS-CoV-2 infection with IC50 of 39 nM in cell-based assays. |
