| Cat. No. |
Product Name |
Information |
| PC-49259 |
SMIP34
|
SMIP34 (Small Molecule Inhibitor of PELP1 34) is a first-in-class, small molecule inhibitor of estrogen receptor (ER) coregulator PELP1, binds to (Kd=37.4 uM) and reduces PELP1 oncogenic functions. |
| PC-49171 |
H3B-6545
|
H3B-6545 is a potent, covalent antagonist of both wild-type and mutant estrogen receptor alpha (ERα), shows antiproliferative activity for ERαWT and ERαY537S overexpressing MCF7 cells with or without H524 L ESR1 mutation with low nM IC50 values. |
| PC-49158 |
JND003
|
JND003 is a potent, selective and orally bioavailable ERRα agonist with EC50 of 86.0 nM for enhancing the interaction between ERRα and PGC1α peptide in AlphaScreen assays, exhibits an EC50 value of 2.7 uM in AAB-Luc cells stably expressing ERRα luciferase reporter. |
| PC-73421 |
Imlunestrant
|
Imlunestrant (LY 3484356) is a potent, oral, selective estrogen receptor degrader (SERD) and pure estrogen receptor antagonist with Ki values of 0.64 nM and 2.8 nM against WT ERα and Y537S mutant ERα proteins, respectively. |
| PC-73108 |
SAR439859
|
SAR439859 (Amcenestrant) is a potent, orally available, selective estrogen receptor degrader (SERD) with IC50 of 0.2 nM (ERα degradation). |
| PC-73046 |
GNE-274
|
GNE-274 (GNE274) is a small molecule non-degrader, partial agonist of estrogen receptor (ER), failed to trigger increased ER turnover in tested cell line. |
| PC-72965 |
GSK5182
|
GSK5182 (GSK-5182) is a highly selective and orally active inverse agonist of estrogen-related receptor γ (ERRγ) with IC50 of 79 nM. |
