| Cat. No. |
Product Name |
Information |
| PC-22966 |
eEF2K Degrader 36
eEF2K degrader
|
eEF2K Degrader 36 is a potent eEF2K degrader with binding KD of 330 nM, DC50 of 319 nM in MDA-MB-231 cells. |
| PC-22415 |
CR-1-31-B
eIF4A inhibitor
|
CR-1-31-B (CR-31) is a potent and specific eIF4A RNA helicase inhibitor, blocks translation of the MUC1-C oncoprotein. |
| PC-22002 |
DNL343
eIF2B activator
|
DNL343 is a potent, selective, and brain-penetrant eIF2B activator with IC50 of 3.2 nM in cellular ATF4 nano-Luciferase (nLuc) reporter assays. |
| PC-22001 |
ABBV-CLS-7262
eIF2B activator
|
ABBV-CLS-7262 (Fosigotifator) is a potent, selective eIF2B activator undergoing clinical development for ALS and vanishing white matter disease. |
| PC-21794 |
eEF2K degrader C1
eEF2K inhibitor
|
eEF2K degrader C1 is a small-molecule degrader of eEF2K, acts a molecular glue to enhance the interaction of eEF2K with the ubiquitin E3 ligase βTRCP, thereby promoting the proteasomal degradation of eEF2K. |
| PC-21688 |
MG-002
eIF4A inhibitor
|
MG-002 is a potent, second-generation, orally bioavailable eIF4A RNA helicase inhibitor, potently inhibits cap-dependent mRNA translation with IC50 of 43 nM. |
| PC-21264 |
Briciclib
eIF4E inhibitor
|
Briciclib (ON 014185) is a small molecule inhibitor of eukaryotic translation initiation factor 4E (eIF4E), downregulates the expression of eIF4E and its two complex partners eIF4A and G, as well as other eIFs (e.g. eIF1A, eIF2α, eIF3A, eIF3B, eIF5 and eIF6). |
| PC-20686 |
SBI-0498
eIF4F inhibitor
|
SBI-0498 (SBI-0730498) is a small molecule inhibitor of coronaviruses translation initiation complex 4F (eIF4F), disrupts eIF4F complex formation and inhibits coronavirus RNA and protein levels. |
| PC-20685 |
SBI-5844
eIF4F inhibitor
|
SBI-5844 (SBI-1275844) is a small molecule inhibitor of coronaviruses translation initiation complex 4F (eIF4F), disrupts eIF4F complex formation and inhibits coronavirus RNA and protein levels. |
| PC-20483 |
eIF4E-RBM38 inhibitor 094
eIF4E-RBM38 inhibitor
|
eIF4E-RBM38 inhibitor 094 (Compound 094) is a first-in-class small molecule inhibitor of eIF4E-RBM38 complex, binds to eIF4E via its C-terminus pocket (Kd=16 uM) and dissociates RBM38 from eIF4E, enhances p53 translation in RBM38- and eIF4E-dependent manners. |
| PC-49309 |
RBF197
eIF4A inhibitor
|
RBF197 (RBF-197) is a novel highly potent and selective eIF4A inhibitor, inhibits human eIF4A helicase activity with IC50 of 55.2 pM. |
| PC-49308 |
eIF4A inhibitor 28
eIF4A inhibitor
|
eIF4A inhibitor 28 (eIF4A-IN-28) is a novel small molecule RNA-competitive, ATP-uncompetitive inhibitor of eIF4A, inhibits eIF4A ATPase and helicase activities with IC50 of 8.6 and 6.6 uM, respectively. |
