| Cat. No. |
Product Name |
Information |
| PC-49222 |
KPT-276
|
KPT-276 (KPT276) is an orally bioavailable selective inhibitor of nuclear export (SINE) that irreversibly bind to CRM1 and block the function of this protein, shows antileukemic activity in vitro and in vivo in acute myeloid leukemia (AML). |
| PC-49221 |
KPT-185
|
KPT-185 (KPT185) is a potent, selective inhibitor of nuclear export (SINE) that irreversibly bind to CRM1 and block the function of this protein, shows antileukemic activity in vitro and in vivo in acute myeloid leukemia (AML). |
| PC-49183 |
LFS-829
|
LFS-829 (LFS829) is a potent, covalent, small-molecule antagonist of exportin-1 (CRM1) with binding Kd values of 26.95 nM in SPR assays, forms a covalent bond with the sulfur atom of Cys539 126 located in the NES binding cleft of CRM1. |
| PC-35933 |
Verdinexor
|
Verdinexor (KPT-335, KPT335) is an orally bioavailable, selective inhibitor of nuclear export (SINE), inhibits the function of nuclear export protein Exportin 1 (XPO1/CRM1) and the viability of Jurkat and canine DLBCL cells with IC50 of 8.7 nM and 13.3 nM, respectively. |
| PC-35581 |
Selinexor
|
Selinexor (KPT-330, KPT330) is a potent, orally available, selective inhibitor of nuclear export (SINE) targeting CRM1 (XPO1). |
| PC-61270 |
KPT-251
|
KPT-251 (KPT251) is a small-molecule, selective inhibitor of nuclear export (CRM1 inhibitor, SINE) that exhibits potent antileukemic activity. |
| PC-42150 |
Eltanexor
|
Eltanexor (KPT-8602) is a second-generation SINE, orally bioavailable Exportin 1 (XPO1,CRM1) inhibitor with markedly reduced brain penetration compared to selinexor (30-fold less). |
