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Cat. No. Product Name Information
PC-38140

Frizzled6 agonist SAG1.3

Frizzled6 agonist SAG1.3 is a small molecule SMO agonist that targets Frizzled6 (FZD6) as a partial agonist with limited subtype selectivity.
PC-60976

FzM1

FzM1 is a negative allosteric modulator of the Frizzled4 (Fzd4) receptor and a Wnt/β-catenin pathway inhibitor with pEC50 value of 5.74 for inhibition of Wnt antagonism.
PC-60975

FzM1.8

FzM1.8 is a small molecule, allosteric agonist of the Frizzled receptor Fzd4 with pEC50 of 6.4, potentiates β-catenin pathway in the absence of any WNT ligand.
PC-60973

SRI 37892

SRI 37892 (SRI37892) is a novel potent, small molecule Frizzled 7 (Fzd 7) inhibitor with IC50 of 0.66 uM in Wnt/β-catenin assay.
PC-60868

NSC654259

NSC654259 is a novel small molecule Wnt signaling inhibitor that targets the cysteine-rich domain of Frizzled, specifically binds to the Wnt binding site on the Frizzled8 cysteine-rich domain with Kd of 2.9 uM, IC50 of 5.7 uM..
PC-21134

FZD7 antagonist 28

FZD7 antagonist 28 is a small molecule antagonist of the transmembrane domain of frizzled receptor FZD7 (FZD7-TMD), blocks Wnt3A-mediated stabilization of β-catenin in HEK293T cells with IC50 of 0.04 uM.
PC-21133

FZD7 antagonist F7H

FZD7 antagonist F7H is a small molecule antagonist of the transmembrane domain of frizzled receptor FZD7 (FZD7-TMD, SPR KD=0.16 uM), blocks Wnt3A-mediated stabilization of β-catenin in HEK293T cells with IC50 of 1.25 uM.

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