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Request The Product List ofGSK-3 GSK-3

Cat. No. Product Name Information
PC-20193

LY2090314

GSK-3 inhibitor

LY2090314 is a potent and selective ATP-competitive inhibitor of Glycogen synthase kinase-3 (GSK-3) with IC50 of 1.5/0.9 nM for GSK3α/GSK3β, respectively.
PC-20191

GSK3 inhibitor 117

GSK-3 inhibitor

GSK3 inhibitor 117 is a novel selective GSK-3 inhibitor, shows cytotoxicity against AML in vitro and in vivo.
PC-20114

GSK-3β inhibitor 47

GSK3β inhibitor

GSK-3β inhibitor 47 is a potent, selective, brain-penetrant, orally bioavailable GSK-3β inhibitor with IC50 of 0.73 nM, inhibits phosphorylated tau with cell IC50 of 58 nM.
PC-49290

Tideglusib

GSK-3 inhibitor

Tideglusib (NP031112, NP-12) is a potent and irreversible small molecule glycogen synthase kinase 3 (GSK-3) inhibitor with IC50 of 60 nM.
PC-49262

SB415286

GSK-3 inhibitor

SB-415286 (SB415286) is a potent, selective, ATP competitive small molecule inhibitor of GSK-3alpha with Ki of 31 nM, inhibits GSK-3beta with similar potency.
PC-38653

ARN25068

GSK-3β/FYN/DYRK1A inhibitor

ARN25068 is a highly potent, triple GSK-3β/FYN/DYRK1A inhibitor with IC50 of 4.17 and 2.17 μM for GSK-3β and FYN, reduces the extent of tau phosphorylation in Tau0N4R-TM-tGFP U2OS cell line.
PC-38527

GSK-3 Inhibitor XIII

GSK-3 inhibitor

GSK-3 Inhibitor XIII is a potent and ATP-binding site inhibitor of GSK-3.
PC-72725

COB-187

GSK-3 inhibitor

COB-187 (COB187) is a highly potent and selective inhibitor of GSK-3 with IC50 of 22/11 nM against GSK-3α/GSK-3β.
PC-63357

MMBO

GSK-3 inhibitor

MMBO is a potent, highly selective, brain penetrant, orally active inhibitor of GSK-3 with IC50 of 37 and 53 nM for GSK-3α and GSK-3β, respectively.
PC-63312

BRD3731

GSK3β inhibitor

BRD3731 is a potent, selective GSK3β inhibitor with IC50 of 15 nM, 14-fold selectivity for GSK3β over GSK3α (IC50=215 nM).
PC-63311

BRD0705

GSK3α inhibitor

BRD0705 is a potent, paralog-selective GSK3α inhibitor with IC50 of 66 nM, 8-fold selectivity over GSK3β (IC50=515 nM).
PC-63239

Methyliodobikinin

GSK3-like kinase BIN2 inhibitor

Methyliodobikinin is a potent bikinin-like inhibitor targeting GSK3/Shaggy-like kinase, shows improved cell permeability, highly potent in vivo although it had lower activity in vitro.

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