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Request The Product List ofHedgehog (Hh) Hedgehog (Hh)

Cat. No. Product Name Information
PC-22129

DS-1-38

EYA1 inhibitor

DS-1-38 (EYA1 inhibits DS38) is a small molecule allosteric inhibitor of EYA proteins and sonic hedgehog (SHH) signaling pathway, binds to EYA1 and inhibits EYA1 phosphatase activity.
PC-49040

HhAg1.5

Hedgehog agonist

HhAg1.5 (SAg1.5) is a small molecule Hedgehog agonist with EC50 of 1 nM, induces cilia translocation of SMO and GLI transcription factor activation, efficiently generates expandable liver stem cells (LSCs) in vitro.
PC-49012

MDB5

Hh pathway inhibitor

MDB5 is a potent hedgehog (Hh) signaling pathway inhibitor, exhibits stronger inhibition of the Hh pathway and anticancer effect in vitro and vivo than GDC-0449.
PC-72867

Rhonin

RHOGDI1 inhibitor

Rhonin is the first small-molecule ligand of the RHO GDP-dissociation inhibitor 1 (RHOGDI1), binds to RHOGDI (Ki=2.2 uM), is an inhibitor of Hh-induced osteogenesis.
PC-63064

Cyclopamine tartrate

Hedgehog inhibitor

Cyclopamine tartrate is a natural steroidal alkaloid that inhibits hedgehog (Hh) signaling with IC50 of 46 nM.
PC-62852

BRD9526

Shh inhibitor

BRD9526 is a potent, small-molecule inhibitor of the Sonic Hedgehog (Shh) pathway with EC50 of 60 nM, partially lowers Gli1 expression at concentrations of 10 uM, a useful probe of Shh signaling pathway. .
PC-62851

BRD50837

Hedgehog inhibitor

BRD50837 is a potent, selective, small-molecule inhibitor of the Sonic Hedgehog (Shh) pathway with EC50 of 90 nM, partially lowers Gli1 expression at concentrations of 2 uM, a useful probe of Shh signaling pathway. .
PC-62179

HPI-1

Hedgehog inhibitor

HPI-1 is a Hedgehog (Hh) pathway inhibitor that suppresses signaling through Shh (IC50=1.5 uM) without significantly affecting Wnt signaling (IC50>30 uM).
PC-60477

TAK-441

Hedgehog inhibitor

TAK-441 is a highly potent, orally active hedgehog signaling (Hh) inhibitor with IC50 of 4.4 nM in Gli-luc reporter assays.
PC-70165

RUSKI-201

Hedgehog acyltransferase inhibitor

RUSKI-201 is a potent, selective and cell active Hedgehog acyltransferase (Hhat) inhibitor with IC50 of 0.87 uM.
PC-45464

RU-SKI 43 hydrochloride

Hedgehog acyltransferase inhibitor

RU-SKI 43 hydrochloride is a small molecule inhibitor of Hhat (Hedgehog acyltransferase) with IC50 of 0.85 uM.
PC-45463

RU-SKI 43

Hedgehog acyltransferase inhibitor

RU-SKI 43 is a small molecule inhibitor of Hhat (Hedgehog acyltransferase) with IC50 of 0.85 uM.

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