| Cat. No. |
Product Name |
Information |
| PC-49209 |
UNC6934
|
UNC6934 is a potent, selective chemical probe ligand targeting the N-terminal PWWP (PWWP1) domain of NSD2 with Kd value of 91 nM, selectively binds in the aromatic cage of NSD2-PWWP1, thereby disrupting its interaction with H3K36me2 nucleosomes. |
| PC-49020 |
TC-E 5003
|
TC-E 5003 is a selective inhibitor of arginine methyltransferase I (PRMT1) with IC50 of 1.5 uM, does not inhibit PRMT4 or the lysine methyltransferase Set7/9. |
| PC-47080 |
MS8511
|
MS8511 is a first-in-class G9a/GLP covalent, irreversible inhibitor with IC50 of 100/140 nM respectively, displays improved potency in enzymatic and cellular assays compare with noncovalent G9a/GLP inhibitor UNC0642. |
| PC-73451 |
Tulmimetostat
|
Tulmimetostat (CPI-0209) is a potent, selective, second-generation EZH2 inhibitor for the treatment of cancers. |
| PC-73322 |
EZM0414
|
EZM 0414 is a potent, selective and orally bioavailable inhibitor of histone methyltransferase SETD2 with biochemical IC50 of 18 nM, >10,000-fold selectivity over other HMTases. |
| PC-73067 |
BR-001
|
BR-001 (BR001) is a potent, selective, allosteric inhibitor of EED subunit of PRC2 complex, disrupts EED-H3K27me3 interaction (IC50=4.5 nM). |
| PC-73054 |
PFI-5
|
PFI-5 a highly biochemically potent, selective, and cell-active SMYD2 chemical probe with IC50 of 8 nM. |
