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Cat. No. Product Name Information
PC-49209

UNC6934

UNC6934 is a potent, selective chemical probe ligand targeting the N-terminal PWWP (PWWP1) domain of NSD2 with Kd value of 91 nM, selectively binds in the aromatic cage of NSD2-PWWP1, thereby disrupting its interaction with H3K36me2 nucleosomes.
PC-49020

TC-E 5003

TC-E 5003 is a selective inhibitor of arginine methyltransferase I (PRMT1) with IC50 of 1.5 uM, does not inhibit PRMT4 or the lysine methyltransferase Set7/9.
PC-47080

MS8511

MS8511 is a first-in-class G9a/GLP covalent, irreversible inhibitor with IC50 of 100/140 nM respectively, displays improved potency in enzymatic and cellular assays compare with noncovalent G9a/GLP inhibitor UNC0642.
PC-73451

Tulmimetostat

Tulmimetostat (CPI-0209) is a potent, selective, second-generation EZH2 inhibitor for the treatment of cancers.
PC-73322

EZM0414

EZM 0414 is a potent, selective and orally bioavailable inhibitor of histone methyltransferase SETD2 with biochemical IC50 of 18 nM, >10,000-fold selectivity over other HMTases.
PC-73067

BR-001

BR-001 (BR001) is a potent, selective, allosteric inhibitor of EED subunit of PRC2 complex, disrupts EED-H3K27me3 interaction (IC50=4.5 nM).
PC-73054

PFI-5

PFI-5 a highly biochemically potent, selective, and cell-active SMYD2 chemical probe with IC50 of 8 nM.

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