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Cat. No. Product Name Information
PC-20879

142D6

142D6 is a potent, Lys-covalent pan-IAP inhibitor, targets the BIR3 domain of the inhibitor of the apoptosis protein (IAP) family with IC50 of 43/21/21 nM for XIAP/cIAP1/cIAP2, respectively.
PC-47055

ARTS mimetic A4

ARTS mimetic A4 is a small molecule that mimics the function of the pro-apoptotic ARTS (Sept4_i2) protein, binds the ARTS pocket in XIAP-BIR3, but not cIAP1, specifically promotes degradation of XIAP and induces caspase-mediated cell death.
PC-63391

ASTX660

Tolinapant (ASTX660) is a novel potent IAP antagonist that targets the BIR3 domain of cIAP1/2 and XIAP with IC50 of 12 nM and <40 nM.
PC-45289

Embelin

Embelin (Embelic acid, Emberine, NSC-91874) is a cell-permeable benzoquinone compound that exhibits antitumor properties.
PC-20999

LBW242

LBW242 (LBW-242) is a small molecule Smac-mimetic / inhibitor of apoptosis protein (IAP) antagonist, binds to XIAP (BIR3) with IC50 of 280 nM.
PC-20998

LCL161

LCL161 is a monovalent Smac-mimetic, binds IAPs with high affinity and initiates the destruction of cIAP1 and cIAP2 (encoded by BIRC2 and BIRC3, respectively) and prevention of caspase inhibition by XIAP.
PC-20236

RMT 5265

RMT 5265 (RMT5265) is a potent, small molecule bivalent mimic of Smac, inhibits XIAP and cIAP1/2 through the BIR3 domain.

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