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Cat. No. Product Name Information
PC-20879

142D6

142D6 is a potent, Lys-covalent pan-IAP inhibitor, targets the BIR3 domain of the inhibitor of the apoptosis protein (IAP) family with IC50 of 43/21/21 nM for XIAP/cIAP1/cIAP2, respectively.
PC-47055

ARTS mimetic A4

ARTS mimetic A4 is a small molecule that mimics the function of the pro-apoptotic ARTS (Sept4_i2) protein, binds the ARTS pocket in XIAP-BIR3, but not cIAP1, specifically promotes degradation of XIAP and induces caspase-mediated cell death.
PC-35889

DEBIO 1143

DEBIO 1143 (Xevinapant, AT-406, SM406, ARRY-334543, D1143) is a potent, orally active Smac mimetic that antagonizes cIAP1, cIAP2 and XIAP with Ki of 66.4, 1.9 and 5.1 nM, respectively.
PC-63391

ASTX660

Tolinapant (ASTX660) is a novel potent IAP antagonist that targets the BIR3 domain of cIAP1/2 and XIAP with IC50 of 12 nM and <40 nM.
PC-43119

AZD5582

AZD5582 is a dimeric Smac mimetic, potent IAP antagonist that binds potently to the BIR3 domains of cIAP1, cIAP2 and XIAP with IC50 of 15, 21and 15 nM, respectively.
PC-45289

Embelin

Embelin (Embelic acid, Emberine, NSC-91874) is a cell-permeable benzoquinone compound that exhibits antitumor properties.
PC-21421

LLP-3

LLP-3 is a potent inhibitor of Survivin protein interaction, sepcifically inhibits Survivin-Ran complex formation, inhibits glioma stem cells (GSC) survival and growth.

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