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Cat. No. Product Name Information
PC-22617

Oclacitinib

JAK inhibitor

Oclacitinib (PF-03394197) is a potent JAK inhibitor with IC50 of 10, 18, 99, and 84 nM for JAK1, JAK2, JAK3, and TYK2, respectively.
PC-22378

TYK2 inhibitor X

TYK2 inhibitor

TYK2 inhibitor X is a potent, selective TYK2 inhibitor.
PC-21734

ATI-1777

JAK1/3 inhibitor

ATI-1777 (Lepzacitinib) is a potent, selective and ATP-competitive JAK1/3 inhibitor with IC50 of 1.5/3.6/7.1/19.0 nM for JAK1/JAK2/JAK3/TYK2, respectively.
PC-21376

MMT3-72

JAK inhibitor

MMT3-72 is a gastrointestinal locally-activating Janus kinase (JAK) inhibitor, readily converted to MMT3-72-M2 in the colon contents (JAK1 IC50=10.8 nM, JAK2 IC50=26.3 nM and TYK2 IC50=91.6 nM).
PC-21236

ABBV-712

TYK2-JH2 inhibitor

ABBV-712 is a potent, selective inhibitor of tyrosine kinase 2 (TYK2) with EC50 of 0.01 uM, binds and stabilizes the pseudokinase (JH2) domain of TYK2.
PC-20516

TAK-279

TYK2 inhibitor

NDI-034858 (Zasocitinib, TAK-279) is a potent, selective and allosteric TYK2 inhibitor, targets TYK2 JH2 domain with binding KD of 3.8 pM.
PC-20143

CEE321

pan JAK inhibitor

CEE321 (CEE-321) is a potent, selective pan-JAK inhibitor with IC50 of 50, 48, 59 and 48 nM for JAK1, JAK2, JAK3 and TYK2, respectively.
PC-20060

Nimucitinib

JAK inhibitor

Nimucitinib is a potent, selective Janus kinase (JAK) inhibitor.
PC-49651

CPL409116

JAK/ROCK inhibitor

CPL409116 (CPL 409116) is a potent, competitive, dual JAK and ROCK inhibitor with IC50 of 0.95/5.36//0.87/110.6/106.7 nM for JAK1/JAK2/JAK3/ROCK1/ROCK2, respectively.
PC-49397

Ifidancitinib

JAK1/3 inhibitor

Ifidancitinib (ATI-502, ATI-50002, R507) is a potent and selective next-generation JAK1/3 inhibitor, potently inhibits γc cytokine signaling.
PC-49377

JAK-IN-21

JAK inhibitor

JAK-IN-21 is a selective and potent JAK inhibitor with IC50 of 1.73, 2.04, 109 and 62.9 nM against JAK1, JAK2, J2V617F and TYK2, respectively.
PC-49343

VVD-118313

JAK1 inhibitor

VVD-118313 (VVD118313) is a potent, selective and allosteric inhibitor of the non-catalytic pseudokinase domain of JAK1 (C817), blocks JAK1-dependent trans-phosphorylation and cytokine signaling.

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