| Cat. No. |
Product Name |
Information |
| PC-26017 |
NS-229
JAK1 inhibitor
|
NS-229 is a potent, selective JAK1 inhibitor with IC50 of 52 nM. |
| PC-25681 |
OB756
JAK2 inhibitor
|
OB756 (Bonretinib) is a potent, selective, oral JAK2 kinase inhibitor, inhibits cell proliferation and induces cell apoptosis, significantly inhibits the phosphorylation activity of p-STAT3 in the JAK-STAT signaling pathway. |
| PC-25191 |
Rovadicitinib
JAK/ROCK inhibitor
|
Rovadicitinib (TQ05105) is a potent, oral dual JAK1/2 and ROCK1/2 inhibitor targeting inflammatory and fibrotic components of chronic graft-versus-host disease (cGVHD). |
| PC-25094 |
Socrodeucitinib
TYK2 inhibitor
|
Socrodeucitinib is a potent, selective, allosteric oral TYK2 inhibitor, selectively inhibits TYK2 cytokine signalling pathways in psoriasis pathogenesis. |
| PC-25062 |
ESK-001
TYK2 inhibitor
|
ESK-001 (Envudeucitinib) is a novel allosteric, highly selective allosteric inhibitor of tyrosine kinase 2 (TYK2) with IC50 of 104-149 nM in human whole blood, binds to JH2 domain of TYK2. |
| PC-25034 |
TUL01101
JAK1 inhibitor
|
Blovacitinib (TUL01101) is a potent, selective and oral Janus kinase 1 (JAK1) inhibitor with IC50 of 3 nM, >12-fold selectivity for JAK2 and TYK2. |
| PC-24147 |
Lirucitinib
JAK inhibitor
|
Lirucitinib (GGW101, GGW 101) is a potent, selective JAK inhibitor. |
| PC-22993 |
Pacritinib
JAK2/FLT3 inhibitor
|
Pacritinib (SB1518) is a potent, selective JAK2/FLT3 inhibitor with IC50 of 23 and 19 nM for JAK2(WT) and JAK2(V617F), and IC50 of 22 nM for FLT3. |
| PC-22617 |
Oclacitinib
JAK inhibitor
|
Oclacitinib (PF-03394197) is a potent JAK inhibitor with IC50 of 10, 18, 99, and 84 nM for JAK1, JAK2, JAK3, and TYK2, respectively. |
| PC-22495 |
MS-1020
JAK3 inhibitor
|
MS-1020 is a selective, ATP-competitive small molecule JAK3 inhibitor, directly blocks JAK3 catalytic activity, potently inhibits persistently-active STAT3 in a cell type-specific manner. |
| PC-22404 |
GLPG3667
TYK2 inhibitor
|
Cadefrecitinib (GLPG3667) is a potent, reversible and selective, ATP-competitive TYK2 inhibitor with IC50 of 2.3 nM. |
| PC-22378 |
TYK2 inhibitor X
TYK2 inhibitor
|
TYK2 inhibitor X is a potent, selective and blood-brain barrier (BBB) permeable TYK2 inhibitor. |
