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Request The Product List ofMixed Lineage Kinase (MLK) Mixed Lineage Kinase (MLK)

Cat. No. Product Name Information
PC-20851

KC-130

KC-130 (KC130, ZAK inhibitor 8) is a potent, selective and covalent leucine-zipper and sterile-α motif kinase (ZAK) inhibitor with IC50 of 11.5 nM.
PC-43118

URMC-099

URMC-099 is a potent, orally bioavailable, brain penetrant inhibitor of mixed lineage kinase 3 (MLK3) with IC50 of 14 nM.
PC-70325

GW 806742X

GW 806742X (T0446) is a small molecule MLKL (Mixed Lineage Kinase Domain-Like) interactor that binds the MLKL pseudokinase domain (Kd=9.3 uM), retards membrane association to inhibit necroptosis.
PC-70175

M-443

M-443 (M443) is a specific, irreversible inhibitor of MLK-related kinase MRK (ZAK), does not inhibit Bcr-Abl.
PC-70174

CEP-1347

CEP-1347 (KT-7515) is a potent and selective MLK inhibitor that completely rescues motoneurons and inhibits JNK1 activation with IC50 of 20 nM.
PC-42202

Necrosulfonamide

Necrosulfonamide is a small molecule covalent inhibitor of mixed lineage kinase domain like protein (MLKL) that specifically blocks necrosis downstream of RIP3 activation.
PC-21159

MLKL inhibitor P28

MLKL inhibitor P28 is a potent inhibitor of necroptosis via MLKL inhibition (EC50=10.3 uM), blocks oligomerization and translocation of MLKL.

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