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Cat. No. Product Name Information
PC-21694

YQ128

NLRP3 inhibitor

YQ128 is potent, second-generation inhibitor of the NOD-like receptor protein 3 (NLRP3) inflammasome with IC50 of 0.3 uM.
PC-21637

ZYIL1

NLRP3 inhibitor

ZYIL1 (Usnoflast) is a potent, orally active, selective NLRP3 inflammasome inhibitor, Nigericin-mediated interleukin (IL)-1β release in isolated microglia cells with IC50 of 43 nM.
PC-21283

NT-0796

NLRP3 inhibitor

NT-0796 is a potent, selective and brain-penetrant NLRP3 inflammasome inhibitor, inhibits IL-1β release from human PBMC cells with IC50 of 0.32 nM.
PC-20956

ADS032

Inflammasome inhibitor

ADS032 (ADS-032) is the first, reversible and stable dual NLRP1 and NLRP3 inflammasome inhibitor, inhibits nigericin‐induced NLRP3‐induced IL‐1β secretion from LPS‐primed iBMDMs with IC50 of 30 uM.
PC-20303

JC124

NLRP3 inhibitor

JC124 is a potent selective NLRP3 inflammasome inhibitor with IC50 of 3.25 uM for inhibition of IL-1β release by LPS/ATP-stimulated J774A.1 cells.
PC-20225

JC2-11

Inflammasome inhibitor

JC2-11 is an anti-inflammasome compound and a pan-inhibitor of the NLRP3, NLRC4, and AIM2 inflammasomes.
PC-49808

FK 565

NOD1 agonist

FK565 is an immunoactive peptide and a nucleotide-binding oligomerization domain (Nod)-1 ligand agonist.
PC-49463

NIC7

NLRP3 inhibitor

NLRP3-inhibitory compound 7 (NIC7) is a small-molecule inhibitor of Nod-like receptor family pyrin domain-containing 3 (NLRP3), inhibits NLRP3-mediated activation of caspase 1 along with the secretion of IL-1β, IL-18, and lactate dehydrogenase.
PC-49396

GDC-2394

NLRP3 inhibitor

GDC-2394 (GDC2394) is a potent and selective NLRP3 inhibitor with IC50 of 5.4 nM (IL-1β inhibition in PBMCs).
PC-49268

NDT-30805

NLRP3 inhibitor

NDT-30805 is a potent and selective small molecule NLRP3 inflammasome inhibitor with IC50 of 13 nM for IL-1β inhibition in PBMCs.
PC-38558

GSK669

NOD2 inhibitor

GSK669 is a potent, selective NOD2 (nucleotide-binding oligomerization domain 2) inhibitor, inhibits muramyl dipeptide (MDP)-induced NOD2-mediated signaling (IC50=0.5 uM), has an IC50 of 3.2 uM for MDP-stimulated IL-8 secretion in HEK293/hNOD2 cells.
PC-38557

GSK717

NOD2 inhibitor

GSK717 is a potent, selective NOD2 (nucleotide-binding oligomerization domain 2) inhibitor, inhibits muramyl dipeptide (MDP)-induced NOD2-mediated signaling, has an IC50 of 400 nM for MDP-stimulated IL-8 secretion in HEK293/hNOD2 cells.

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