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Goflikicept (RPH-104) is a heterodimeric fusion protein containing IL-1R1 and IL-1RAcP linked to immunoglobulin heavy chains and is highly selectively binds IL-1B, affecting IL-1B signalling pathways, inhibits widespread inflammation.


Trebananib (AMG 386) is a first-in-class peptide-Fc fusion protein (peptibody) that inhibits angiogenesis by preventing the interaction of angiopoietin-1 (Ang1) and Ang2 with their receptor, Tie2.


Batiraxcept (AVB‐S6‐500, AVB-500) is a first-in-class Fc fusion protein of the extracellular domain of AXL that binds the GAS6 ligand thereby inhibiting AXL signaling.


LIB003 (Lerodalcibep) is an engineered PCSK9 protein inhibitor for the treatment of hypercholesterolemia. Anti-(human proprotein convertase subtilisin/kexin type 9), derived from human tenth fibronectin type III domain, fused via peptidyl linker (97GSGSGS102) to human serum albumin (103-687), variant (C34>A136), produced in Chinese hamster ovary (CHO) cells.

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