| Cat. No. |
Product Name |
Information |
| PC-20665 |
ARV-766
|
ARV-776 (Luxdegalutamide, ARV776) is potent, orally bioavailable PROTAC androgen receptor (AR) degrader that degrades not only wild-type AR but also clinically relevant AR LBD mutants, including the most prevalent AR L702H, H875Y, and T878A mutations. |
| PC-20356 |
UNC8153
|
UNC8153 (UNC 8153) is a selective NSD2-targeted degrader with binding Kd of 24 nM for NSD2, potently and selectively reduces cellular levels of both NSD2 protein (DC50=350 nM) and H3K36me2 chromatin mark. |
| PC-20168 |
ZZ151
|
ZZ151 (ZZ-151) is a highly potent and selective SOS1 degrader PROTAC with DC50 of 15.7 nM (Dmax=100%). |
| PC-49629 |
AK-2292
|
AK-2292 (AK2292) is a first, potent and selective small-molecule degrader of both STAT5A and STAT5B isoforms. |
| PC-49622 |
MS147
|
MS147 (MS 147) is the first degrader of PRC1 core components, BMI1 and RING1B, comprises an EED small-molecule binder (EED226, Cat. PC-42321) linked to a ligand of the E3 ligase von Hippel-Lindau (VHL), degrades BMI1/RING1B in an EED-, VHL-, ubiquitination-, and time-dependent manner. |
| PC-49392 |
UBX-382
|
UBX-382 (UBX382) is a potent and orally available proteolysis-targeting chimera (PROTAC) that induces potent BTK degradation in DLBCL cell line with DC50 of 4.5 nM. |
| PC-49380 |
INY-06-061
|
INY-06-061 is a potent and selective heterobifunctional degrader of ERK5 with binding Kd of 12 nM and DC50 of 21 nM in MOLT4 cells (5h treatment). |
