| Cat. No. |
Product Name |
Information |
| PC-22612 |
BRD9 PROTAC E5
BRD9 PROTAC
|
BRD9 PROTAC E5 is a highly potent, selective BRD9 PROTAC degrader with DC50 of 16 pM, IC50 of 0.27 nM for antiproliferation in MV4-11 cells. |
| PC-22591 |
UNC8153 TFA
NSD2 PROTAC
|
UNC8153 (UNC 8153) TFA is a selective NSD2-targeted degrader with binding Kd of 24 nM for NSD2, potently and selectively reduces the cellular levels of both NSD2 protein (DC50=350 nM) and the H3K36me2 chromatin mark. |
| PC-22586 |
dWIZ-2
WIZ degrader
|
dWIZ-2 is a small molecular glue degrader of the WIZ transcription factor and CRBN-based small-molecule inducer of fetal hemoglobin (HbF) in erythroblasts. |
| PC-22356 |
GT-653
KDM5B degrader
|
GT-653 is a potent, selective and effective KDM5B PROTAC degrader based on CPI-455, induces KDM5B degradation via PROTAC mechanism and ubiquitin proteasome system dependent manner. |
| PC-22345 |
EP300 degrader MC-1
EP300 PROTAC
|
EP300 degrader MC-1 is a specific, bifunctional small molecule EP300 degrader, preferentially degrades EP300 in a proteasome-dependent manner, does not degrade CREBBP. |
| PC-22174 |
MS181
PRC1 degrader
|
MS181 is a first-in-class CRBN-recruiting and EED-binding (Kd=190 nM) polycomb repressive complex 1 (PRC1) degrader, preferentially degrades PRC1 components BMI1 and RING1B over PRC2 components EZH2 and SUZ12. |
| PC-22120 |
ARV-393
BCL6 degrader
|
ARV-393 is a potent, orally bioavailable BCL6 targeting PROTAC degrader with DC50 and GI50 values <1 nM in numerous DLBCL and BL cell lines. |
| PC-22055 |
AU-24118
mSWI/SNF ATPase PROTAC
|
AU-24118 is a potent, selective, and orally bioavailable degrader of mSWI/SNF ATPases (SMARCA2, SMARCA4) and PBRM1. |
| PC-21848 |
GNE-0011
BRD4 degrader
|
GNE-0011 is a monovalent, JQ1-based BRD4 degrader that is not linked to an E3 ligase binder, triggers proteasomal and ubiquitin-dependent selective degradation of BRD4 over BRD2 and BRD3. |
| PC-21676 |
WD6305
METTL3-METTL14 PROTAC
|
WD6305 is a potent and selective proteolysis-targeting chimera (PROTAC) degrader of METTL3-METTL14 complex with DC50 of 140 nM (METTL3), Dmax of 91.9% in Mono-Mac-6 AML cell line. |
| PC-21662 |
ACBI3
pan-KRAS PROTAC
|
ACBI3 is a selective, potent and in vivo active pan-KRAS PROTAC degrader, potently degrades 13 out of 17 of the most prevalent oncogenic KRAS alleles (DC50=3.9 nM in GP2d cells). |
| PC-21653 |
DAS-CHO-5-oCRBN
c-Src PROTAC
|
DAS-CHO-5-oCRBN is a potent and selective PROTAC for c-Src kinase with DC50 value of 55 nM in CAL148 cells. |
