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Cat. No. Product Name Information
PC-49126

GNE-684

GNE-684 is a potent, cross-species, specific RIP1 kinase (RIPK1) inhibitor with IC50 of 21, 189 and 691 nM for human, mouse and rat RIP1, respectively.
PC-47116

AS3334034

AS3334034 is a potent, selective inhibitor of the receptor-interacting protein kinase 2 (RIPK2) with IC50 of 3.02 and 2.10 nM for rat and human RIP2 kinase activity, respectively.
PC-73179

GSK2983559-AM

GSK2983559-AM is the acitve form of GSK2983559, a potent, selective RIPK2 with IC50 of 5 nM.
PC-73017

PK68

PK68 (RIPK1 inhibitor PK68) is a potent necroptosis inhibitor seletively targeting RIPK1 kinase activity, potently inhibits TNF-induced necroptosis (EC50, 23 and 13 nM in human and mouse cells, respectively).
PC-73007

sNecrostatin-34

Necrostatin-34 (Nec-34) is a novel small molecule inhibitor of RIPK1 kinase, inhibits TNFα-induced necroptosis in FADD-deficient Jurkat cells with IC50 of 0.67 uM.
PC-72999

GSK3145095

GSK3145095 (GSK 3145095) is a potent, selective RIP1 Kinase (RIP1) inhibitor with IC50 of 6.3 nM.
PC-72533

Eclitasertib

Eclitasertib (DNL-758, SAR-443122) is a potent, orally bioavailable, small-molecule RIPK1 inhibitor with IC50 of <1 uM.

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