| Cat. No. |
Product Name |
Information |
| PC-49126 |
GNE-684
|
GNE-684 is a potent, cross-species, specific RIP1 kinase (RIPK1) inhibitor with IC50 of 21, 189 and 691 nM for human, mouse and rat RIP1, respectively. |
| PC-47116 |
AS3334034
|
AS3334034 is a potent, selective inhibitor of the receptor-interacting protein kinase 2 (RIPK2) with IC50 of 3.02 and 2.10 nM for rat and human RIP2 kinase activity, respectively. |
| PC-73179 |
GSK2983559-AM
|
GSK2983559-AM is the acitve form of GSK2983559, a potent, selective RIPK2 with IC50 of 5 nM. |
| PC-73017 |
PK68
|
PK68 (RIPK1 inhibitor PK68) is a potent necroptosis inhibitor seletively targeting RIPK1 kinase activity, potently inhibits TNF-induced necroptosis (EC50, 23 and 13 nM in human and mouse cells, respectively). |
| PC-73007 |
sNecrostatin-34
|
Necrostatin-34 (Nec-34) is a novel small molecule inhibitor of RIPK1 kinase, inhibits TNFα-induced necroptosis in FADD-deficient Jurkat cells with IC50 of 0.67 uM. |
| PC-72999 |
GSK3145095
|
GSK3145095 (GSK 3145095) is a potent, selective RIP1 Kinase (RIP1) inhibitor with IC50 of 6.3 nM. |
| PC-72533 |
Eclitasertib
|
Eclitasertib (DNL-758, SAR-443122) is a potent, orally bioavailable, small-molecule RIPK1 inhibitor with IC50 of <1 uM. |
