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Cat. No. Product Name Information
PC-22523

PF-07799933

mutant BRAF inhibitor

PF-07799933 (ARRY-440) is a brain-penetrant, selective, pan-mutant BRAF inhibitor, demonstrated broad inhibition of pERK levels in cell lines harboring Class I (IC50=0.7-7 nM), II (10-14 nM), III (0.8, 7.8 nM), and indel (113, 179 nM) mutations, acquired BRAF p61 splice variant (59 nM), and acquired NRAS-Q61K (16 nM), but significantly spared pERK in BRAF wild-type cells (≥9800 nM).
PC-22122

NST-628

RAF-MEK molecular glue

NST-628 is a potent, brain-penetrant, pan-RAF-MEK molecular glue, prevents phosphorylation and activation of MEK by RAF, leading to deep durable inhibition of MEK kinase activity and downstream ERK signaling.
PC-21386

Uplarafenib

BRAF inhibitor

Uplarafenib is a potent, selective small molecule inhibitor of BRAF kinase (IC50=50-100 nM) with antineoplastic activities.
PC-21219

Exarafenib

pan-RAF inhibitor

Exarafenib (KIN-2787) is a highly potent and selective pan-RAF inhibitor with IC50 of 2.4/3.5/1.4 nM for ARAF/BRAF/CRAF, respectively.
PC-20793

IHMT-RAF-128

pan-RAF inhibitor

IHMT-RAF-128 is a highly potent pan-RAF inhibitor with IC50 of 5.9 and 3.6 nM for BRAF-V600E and CRAF, respectively.
PC-49770

Encorafenib

BRAF inhibitor

Encorafenib (NVP-LGX818, LGX818) a potent, selective BRAF inhibitor with IC50 of 0.35, 0.47, and 0.3 nM against BRAF V600E, wild-type BRAF and CRAF in vitro cell-free assays, respectively.
PC-73450

AZ-628

pan-RAF inhibitor

AZ628 (AZD-628) is a potent, selective, pan-RAF kinase inhibitor with IC50 of 105, 29 and 34 nM against for wild-type CRAF, BRAF V600E, and c-Raf-1, respectively.
PC-73449

Tovorafenib

pan-RAF inhibitor

Tovorafenib (MLN2480, TAK-580) is potent, selective, brain-penetrant RAF dimer antagonist, inhibits MAP kinase pathway signaling in BRAF-mutant melanoma models.
PC-72612

PF-07284890

BRAF V600 mutants inhibitor

Tinlorafenib (PF-07284890, ARRY-461) is an orally bioavailable, brain penetrant, potent, small molecule BRAF V600 mutants inhibitor, inhibits BRAF and CRAF with IC50 of 5.8 and 4.1 nM, respectively.
PC-72530

TAK-632

pan-RAF inhibitor

TAK-632 (TAK632) is a potent, selective pan-RAF inhibitor with IC50 of 1.4, 2.4 and 8.3 nM for CRAF, BRAF V600E and BRAF WT, respectively.
PC-72469

GNE-9815

pan-RAF inhibitor

GNE-9815 (GNE9815) is a potent, selective, oral Type II pan-RAF inhibitor with Ki of 0.062 and 0.19 nM for CRAF and BRAF, respectively.
PC-72243

BRAF inhibitor Compound Ia

BRAF inhibitor

BRAF inhibitor Compound Ia is a potent, selective, brain penetrant BRAF inhibitor with binding Kd of 0.6, 1.2, and 1.7 nM for BRAF WT, BRAF V600E, and c-RAF, presenting paradox breaker properties.

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