| Cat. No. |
Product Name |
Information |
| PC-72612 |
PF-07284890
|
PF-07284890 (ARRY-461) is an orally bioavailable, brain penetrant, potent, small molecule BRAF V600 mutants inhibitor, inhibits BRAF and CRAF with IC50 of 5.8 and 4.1 nM, respectively. |
| PC-72469 |
GNE-9815
|
GNE-9815 (GNE9815) is a potent, selective, oral Type II pan-RAF inhibitor with Ki of 0.062 and 0.19 nM for CRAF and BRAF, respectively. |
| PC-72243 |
BRAF inhibitor Compound Ia
|
BRAF inhibitor Compound Ia is a potent, selective, brain penetrant BRAF inhibitor with binding Kd of 0.6, 1.2, and 1.7 nM for BRAF WT, BRAF V600E, and c-RAF, presenting paradox breaker properties. |
| PC-72242 |
PLX8394
|
PLX8394 (Plixorafenib, PLX-8394) is a next-generation, orally available, small-molecule BRAF inhibitor with IC50 values of 3.8 nM, 14 nM and 23 nM for BRAF (V600E), WT BRAF and CRAF, respectively. |
| PC-35635 |
LXH254
|
LXH254 (Naporafenib, LXH 254) is a highly potent, selective B/C RAF inhibitor with Kd of 1.3/3.6 nM respectively, shows less activity against ARAF. |
| PC-42871 |
Vemurafenib
|
Vemurafenib (PLX-4032, RG7204, RO5185426) is a potent, selective B-RAF V600E inhibitor with IC50 of 30 nM, displays similar potency for c-RAF-1 (IC50=48 nM), and has selectivity against many other kinases, including wild type B-RAF (IC50=100nM). |
| PC-63027 |
SB-699393
|
SB-699393 is a potent, selective and CNS penetrant B-Raf inhibitor with Kd of 7.2 nM. |
