| Cat. No. |
Product Name |
Information |
| PC-38549 |
AZD4625
|
AZD4625 is a potent, selective, covalent allosteric inhibitor of mutant GTPase KRAS G12C with IC50 of 3 nM, inhibitor H358 cell proliferation with GI50 of 4 nM. |
| PC-38438 |
MRTX-EX185
|
MRTX-EX185 (EX185) is a novel potent small-molecule inhibitor of KRAS mutants, exhibits target engagement against KRAS(G12D) with IC50 of 90 nM, binds to GDP-loaded KRAS and KRAS(G12D), as well as the active GNP state. |
| PC-73419 |
Garsorasib
|
Garsorasib (D-1553) is a potent, selective, orally bioavailable and covalent KRas-G12C inhibitor with IC50 of 10 nM, exhibits potent anti-tumor activity in a broad spectrum of tumor cell lines. |
| PC-73367 |
DW0254
|
DW0254 (DW-0254) is a small molecules capable of inhibiting RAS-related C3 botulinum toxin substrate (RAC) small GTPase activation in ALL cell lines, directly binds to the hydrophobic pocket of PDE6D (Kd=436 nM, ITC), a RAS chaperone protein. |
| PC-73323 |
GDC-6036
|
GDC-6036 (Divarasib, RG6330) is a potent, selective, covalent and orally available KRAS G12C inhibitor with HTRF IC50 of 2.9 pM. |
| PC-73313 |
MRTX 0902
|
MRTX0902 is a highly potent, selective SOS1 inhibitor with binding IC50 of 2 nM, cellular IC50 of 33 nM (pERK). |
| PC-73069 |
Sotorasib
|
Sotorasib (AMG510) is a potent, selective, covalent KRAS G12C inhibitor with p-ERK IC50 of 68 nM. |
