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Cat. No. Product Name Information
PC-20271

40569Z

SIRT7 inhibitor

40569Z is a specific SIRT7 inhibitor, significantly inhibits SIRT7 deacetylation activity without effects on SIRT1 and SIRT6 activities, induces apoptosis and increases chemosensitivity to sorafenib in human liver cancer.
PC-20270

2800Z

SIRT7 inhibitor

2800Z is a specific SIRT7 inhibitor, significantly inhibits SIRT7 deacetylation activity without effects on SIRT1 and SIRT6 activities, induces apoptosis and increases chemosensitivity to sorafenib in human liver cancer.
PC-20269

MDL-811

SIRT6 activator

MDL-811 (MDL811) is a potent, selective and allosteric SIRT6 activator with EC50 of 5.7 uM (activated SIRT6 deacetylation), two-fold greater activity than MDL-800 (EC50=12.3 uM, Cat# 35760).
PC-49248

JYQ-42

SIRT6 inhibitor

JYQ-42 is a potent, selective SIRT6 allosteric inhibitor, effectively inhibits SIRT6 deacetylation with IC50 of 2.33 uM, inhibits the deacetylation activity of SIRT6 in pancreatic cancer cell lines.
PC-49081

MC3138

SIRT5 activator

MC3138 is a potent and selective small-molecule SIRT5 activator, inhibits proliferation in SIRT5-low PDAC cell lines and organoids.
PC-47061

SRT2104

SIRT1 activator

SRT2104 (GSK2245840) is a highly selective small molecule activator of the NAD+ dependent deacetylase SIRT1.
PC-38543

AGK2

SIRT2 inhibitor

AGK2 is a cell-permeable, selective inhibitor of SIRT2 with IC50 of 3.2 uM, shows minimally affects either SIRT1 or SIRT3 at 10-fold higher levels.
PC-38461

SIRT7 inhibitor 97491

SIRT7 inhibitor

SIRT7 inhibitor 97491 is a novel specific inhibitor of SIRT7 with IC50 of 0.325 uM, reduces deacetylase activity of SIRT7 in a dose-dependent manner.
PC-72771

YC8-02

SIRT3 inhibitor

YC8-02 is a small molecule mitochondrial-targeting SIRT3 inhibitor with IC50 of 0.53 uM.
PC-72770

NH4-6

pan SIRT1-3 inhibitor

NH4-6 is a potent pan SIRT1-3 inhibitor with IC50 of 3.0/0.032/2.3 uM for SIRT1/2/3, respectively.
PC-72769

NH4-13

SIRT2 inhibitor

NH4-13 is a potent, SIRT2-selective inhibitor with IC50 of 87 nM, shows no inhibition against SIRT1/3/5/6 (IC50>50 uM).
PC-72768

NRD167

SIRT5 inhibitor

NRD167 is a potent and selective, cell-permeant SIRT5 inhibitor.

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