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Cat. No. Product Name Information
PC-49248

JYQ-42

JYQ-42 is a potent, selective SIRT6 allosteric inhibitor, effectively inhibits SIRT6 deacetylation with IC50 of 2.33 uM, inhibits the deacetylation activity of SIRT6 in pancreatic cancer cell lines.
PC-49081

MC3138

MC3138 is a potent and selective small-molecule SIRT5 activator, inhibits proliferation in SIRT5-low PDAC cell lines and organoids.
PC-47061

SRT2104

SRT2104 (GSK2245840) is a highly selective small molecule activator of the NAD+ dependent deacetylase SIRT1.
PC-38543

AGK2

AGK2 is a cell-permeable, selective inhibitor of SIRT2 with IC50 of 3.2 uM, shows minimally affects either SIRT1 or SIRT3 at 10-fold higher levels.
PC-72771

YC8-02

YC8-02 is a small molecule mitochondrial-targeting SIRT3 inhibitor with IC50 of 0.53 uM.
PC-72770

NH4-6

NH4-6 is a potent pan SIRT1-3 inhibitor with IC50 of 3.0/0.032/2.3 uM for SIRT1/2/3, respectively.
PC-72768

NRD167

NRD167 is a potent and selective, cell-permeant SIRT5 inhibitor.

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