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TRAP1 inhibitor

SB-U015 is a MitoQ derivative and tumor necrosis factor receptor-associated protein 1 (TRAP1) inhibitor.


TRAP1 inhibitor

SMTIN-C10 is a potent, allosteric tumor necrosis factor receptor-associated protein-1 (TRAP1) inhibitor with IC50 of 1.88 uM, by conjugating TPP a C10 linker, and PU-H71.

Liquidambaric acid

TRAF2 inhibitor

Liquidambaric acid (Betulonic acid) ia a natural compound inhibiting oncogenic Wnt/β-catenin signaling in vitro and in vivo, directly targets tumor necrosis factor receptor-associated factor 2 (TRAF2) with Kd of 6.02 uM in MST assays.


TNF inhibitor

UCB-9260 is a specific, orally active compound, inhibits tumour necrosis factor (TNF) signaling by stabilising an asymmetric form of the trimer, binds to TNF with Kd of 13 nM.

TNFR1 inhibitor FKC

TNFR1 inhibitor

TNFR1 inhibitor FKC is an allosteric inhibitor targets TNFR1 (Tumor necrosis factor receptor 1), inhibits TNFR1 activation by altering the conformational states of the receptor dimer without blocking receptor-ligand interaction or disrupting receptor dimerization.

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