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Cat. No. Product Name Information
PC-21291

TopBP1 inhibitor 5D4

TopBP1

TopBP1 inhibitor 5D4 is a small-molecule inhibitor of TopBP1 (topoisomerase IIβ-binding protein 1), specifically targets the BRCT7/8 domains of TopBP1, blocks MYC activity by freeing MIZ1, a MYC inhibitor, from TopBP1.
PC-49522

c-Myc inhibitor DJ34

c-Myc inhibitor

DJ34 is a novel compound that induces dual c-Myc depletion and p53 activation in a wide range of tumor cell types, DJ34 is a DNA intercalator and topoisomerase II inhibitor, interferes with c-Myc synthesis.
PC-49220

VPC-70063

c-Myc inhibitor

VPC-70063 (VPC70063) is a small molecule Myc inhibitor that inhibits Myc-Max transcriptional activity with IC50 of 8.9 uM in c-Myc luciferase reporter assay in LNCaP cells, disrupts the interaction of Myc-Max with DNA.
PC-47053

D089

Myc inhibitor

D089 is a selective small molecule stabilizer of the MYC G4-quadruplex, not only inhibits MYC expression in myeloma cell lines, but also selectively induces G1 arrest in MYC-driven cancer cell lines containing the MYC-G4 sequence.
PC-38695

MYRA-B

c-MYC inhibitor

MYRA-B (NSC45641) is a small molecule that induces Myc-dependent apoptosis without affecting Myc transactivation or Myc/Max DNA binding.
PC-38694

MYRA-A

c-MYC inhibitor

MYRA-A (NSC339585) is a small molecule Myc pathway response agent (MYRA) that inhibits Myc transactivation and interferes with the DNA-binding activity of Myc family proteins, with no effect on the E-box-binding protein USF.
PC-38693

KSI-3716

c-MYC inhibitor

KSI-3716 is a small molecule c-MYC inhibitor that blocks c-MYC/MAX binding to target gene promoters, inhibits c-MYC mediated transcriptional activity at concentrations as low as 1 uM.
PC-38661

L755507

c-Myc-MAX inhibitor

L755507 is a potent, selective β3-adrenoceptor (β3-AR) agonist, exhibits robust concentration-dependent increase in cAMP accumulation in CHO-K1 cells expressing human β3-adrenoceptors (pEC50=12.3), also effectively inhibits the c-Myc-MAX heterodimerization.
PC-38523

F1021-0686

c-Myc inhibitor

F1021-0686 is a novel small molecule inhibitor of c-Myc, causes the functional repression of c-Myc target gene, shows appreciable anticancer activity against c-Myc expressing cell lines (HT29, IC50=1.55 uM).
PC-38522

F0909-0360

c-Myc inhibitor

F0909-0360 is a novel small molecule inhibitor of c-Myc, causes the functional repression of c-Myc target gene, shows appreciable anticancer activity against c-Myc expressing cell lines (HT29, IC50=0.2 uM).
PC-38503

Mycro3

Myc inhibitor

Mycro3 is a selective small molecule inhibitor of Myc/Max dimerization with IC50 of 40 uM with a cognate-binding site, inhibits DNA binding of c-Myc with preference over other dimeric transcription factors in vitro.
PC-38435

3JC48-3

c-Myc inhibitor

3JC48-3 is a potent, cellularly active and stable c-Myc inhibitor, inhibits c-Myc-max dimerization with IC50 of 34 uM, 5 times more potent than 10074-G5, exhibits an approximate twofold selectivity for c-Myc-Max heterodimers over Max-Max homodimers.

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