| Cat. No. |
Product Name |
Information |
| PC-42746 |
Farampator
AMPAR PAM
|
Farampator (CX-691, Org24448) is a positive allosteric modulator of AMPAR as ampakine agent. |
| PC-45344 |
Sunifiram
AMPAR agonist
|
Sunifiram (DM-253) is a piperazine derived ampakine-like agent, is an agonist of AMPA receptor with oral activity, exhibits potent cognitive enhancement effects with better nootropic activity compared to piracetam. |
| PC-27572 |
IEM-1754
GluR2-lacking AMPAR antagonist
|
IEM-1754 is a selective antagonist of GluR2-lacking AMPA receptors (AMPAR) with KD of 12.0 uM (−80 mV), has >80-fold selectivity over GluR2-containing AMPAR. |
| PC-27571 |
IEM-1925
GluR2-lacking AMPAR antagonist
|
IEM-1925 is a selective antagonist of GluR2-lacking AMPA receptors (AMPAR) with KD of 1.1 uM (−80 mV), >100-fold selective over GluR2-containing AMPAR. |
| PC-27552 |
GYKI-53655
AMPAR antagonist
|
GYKI-53655 (GYKI 53655, LY300168) is a non-competitive AMPA receptor antagonist with IC50 of 5.9 uM. |
| PC-27551 |
UBP310
Kainate receptor antagoist
|
UBP310 is a high affinity, selective antagonist of kainate receptor GluR5 with Kd of 130 nM, has >800-fold selecitvity over GluR2 and GluR6, binds to GluK1 with KD of 21 nM, but shows no specific binding to GluK2. |
| PC-27330 |
GluN2A NAM 6a
GluN2A inhibitor
|
GluN2A NAM 6a is a potent, selective nonsulfonamide GluN2A negative allosteric modulator / inhibitor with IC50 of 3.91 uM, with no activity against GluN2B/C/D. |
| PC-27283 |
CX717
AMPAR PAM
|
CX717 is a positive allosteric modulator of AMPA receptors, prevents opiate-induced respiratory depression, shows antidepressant activities. |
| PC-26935 |
Memantine
NMDA receptor antagonist
|
Memantine is an orally active, noncompetitive N-methyl-D-aspartate receptor (NMDAR) antagonist with Ki of 0.19 uM for competing with [3H]MK-801 binding in membrane homogenates of postmortem human frontal cortex. |
| PC-26837 |
Fluoroethylnormemantine
NMDA receptor antagonist
|
Fluoroethylnormemantine (FENM) is a structural analogue of Memantine and NMDA receptor antagonist with Ki of 3.5 uM, exhibits anti-amnesic, neuroprotective, antidepressant-like and fear-attenuating effects. |
| PC-26348 |
Otefprodil
GluN2B antagonist
|
Otefprodil is a potent, selective antagonist of NR2B (GluN2B)-containing NMDA receptors, inhibits glutamic acid and glycine induced activation. |
| PC-26281 |
CGP-78608 hydrochloride
GluN1 antagonist
|
CGP 78608 hydrochloride is a highly potent and selective antagonist of GluN1/GluN3 NMDAR, antagonizes GluN1/GluN2 receptors, acts as an ultra-potent and powerful potentiator of GluN1/GluN3A receptors. |
