γ-secretase modulator 14a |CAS:1485066-18-9 Probechem Biochemicals

Chemical Structure : γ-secretase modulator 14a

γ-secretase modulator 14a

Catalog No.: PC-60155Not For Human Use, Lab Use Only.

A potent, selective, orally active γ-secretase modulator with Aβ42 IC50 of 39 nM.

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Biological Activity

A potent, selective, orally active γ-secretase modulator with Aβ42 IC50 of 39 nM; shows good to excellent selectivity for the reduction of Aβ42 in the cellular assays; significantly reduces Aβ42 in the CNS compartment in vivo in nontransgenic rat models.

Physicochemical Properties

M.Wt	418.472
Formula	C24H23FN4O2
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(4-fluorophenyl)-3-(3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl)-4,5,6,7-tetrahydrobenzo[d]isoxazol-7-amine

References

1. Zhao Z, et al. ACS Med Chem Lett. 2017 Sep 19;8(10):1002-1006.

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