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Cat. No. Product Name Information
PC-21414

TP-0184

Itacnosertib (TP-0184) is a novel potent, selective inhibitor of type I bone morphogenetic protein (BMP) receptor ACVR1 (activin A receptor-type 1, ALK2) and FLT3 with IC50 of 8.0 nM (ALK2).
PC-21392

NUCC-555

NUCC-555 is a selective antagonist of Activin antagonist, shows dose-dependent antagonistic activity against activin A-stimulated FSHβ promoter activation in 338FSHβ-luc LβT2 cells with IC50 of 3.67 uM.
PC-49109

SY-LB-35

SY-LB-35 is a highly effective small molecule full agonist of bone morphogenetic protein (BMP) receptor signaling, significantly increases the cell number and cell viability in the C2C12 myoblast cell line.
PC-72935

C381

C381 (SRI011381) is a first-in-class, CNS bioactive compound capable of restoring lysosomal function with prominent antiinflammatory and neuroprotective activities.
PC-72619

PF-06952229

PF-06952229 (MDV6058) is a potent, selective and orally active TGFBR1 (ALK5) inhibitor with IC50 of 24 nM.
PC-35519

BLU-782

Fidrisertib (BLU-782) is a potent, selective inhibitor of ALK2 (ACVR1) mutant R206H with IC50 of <10 nM.
PC-63322

JL5

JL5 is a novel potent, selective BMP receptor inhibitor with IC50 of 1, <5 and 2 nM for ALK2/ACVR1, ALK3/BMPR1A and ALK6/BMPR1B, respectively.

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