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Cat. No. Product Name CAS No. Information
PC-72548

KH-4-43

2813310-07-3 KH-4-43 is a small moelcule E3 CRL4 inhibitor and exhibits antitumor potential, directly and selectively binds to the purified E3 ROC1-CUL4A CTD complex with Kd of 83 nM.
PC-72478

BC1618

2222094-18-8 BC1618 (BC-1618) a novel inhibitor of orphan ubiquitin E3 ligase subunit protein Fbxo48, interrupts Fbxo48/pAmpkα interaction and increases pAmpkα levels.
PC-38305

PRC1 inhibitor RB-3

2396639-11-3 PRC1 inhibitor RB-3 (RB-3) is a small molecule PRC1 inhibitor that directly bind to RING1B-BMI1 (KD=2.8 uM), the heterodimeric complex constituting the E3 ligase activity of PRC1.
PC-38239

MS.001

53619-67-3 MS.001 is a small molecule that inhibits both the chaperone binding and ubiquitin ligase activity of C-terminus of Hsc70 interacting protein (CHIP) at low micromolar concentrations (IC50=3.3 uM).
PC-38106

MyoMed-205

2614161-13-4 MyoMed-205 is a small moelcule that inhibits MuRF1 (TRIM63) activity and MuRF1/MuRF2 expression.
PC-35959

HOIPIN-8

2519537-69-8 HOIPIN-8 (HOIP inhibitor-8) is a potent chemical inhibitor of linear ubiquitin chain assembly complex (LUBAC, IC50=11 nM), specifically generates Met1-linked linear ubiquitin chains through the ubiquitin ligase activity in HOIP, and activates the NF-kB pathway.
PC-35913

HS-152

2284548-09-8 HS-152 (HS152) is a specific small-molecule inhibitor of SMAD ubiquitin regulatory factor 1 (SMURF1), not only potently inhibits SMURF1-mediated RHOB degradation with IC50 of 3.2 uM, but also strongly blocks SMURF1-mediated RHOA and SMAD1 degradation (IC50 4.4 uM and 2.1 uM, respectively).

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