| Cat. No. |
Product Name |
Information |
| PC-27969 |
SB33-0223
TRIM21 inhibitor
|
SB33-0223 is a small molecule inhibitor of E3 ubiquitin ligase TRIM21, targets the C-terminal PRYSPRY domain of the TRIM21 protein, inhibits TRIM21-mediated ubiquitination of INTS3 by weakening the TRIM21-INTS3 interaction, attenuates cisplatin-induced DNA damage. |
| PC-27693 |
SMER3
SCFMet30 inhibitor
|
SMER3 is a specific small molecule inhibitor of E3 ubiquitin ligase SCFMet30, a member of SCF family E3 ubiquitin ligases. |
| PC-27386 |
HPV E7-ZER1 inhibitor Compound 4
E7-ZER1 inhibitor
|
HPV E7-ZER1 inhibitor Compound 4 (ZER1-IN-1) is a first-in-class small-molecule inhibitor of ZER1 ARM-repeat domain, selectively blocks the ZER1-E7 interaction, leading to retinoblastoma (Rb) stabilization, inhibition of HPV-positive cervical cancer cell proliferation. |
| PC-26969 |
D665-1412
RNF126 inhibitor
|
D665-1412 is a specific small-molecule inhibitor of E3 ligase RNF126, blocks hypoxia-induced pexophagy, stabilizes peroxisomes, normalizes lipid metabolism, and reactivates hepatocytic differentiation markers, thereby redifferentiating HCC cells and suppressing tumor progression in vitro and in vivo. |
| PC-26726 |
PELI1 inhibitor BZ61
PELI1 inhibitor
|
PELI1 inhibitor BZ61 is a small molecule inhibitor of E3 ubiquitin ligase Pellino-1 (PELI1) with SPR Kd of 1.985 uM, suppresses the proliferation of both tyrosine kinase inhibitors (TKIs)-sensitive and TKI-resistant CML cells. |
| PC-26725 |
PELI1-IN-1
PELI1 inhibitor
|
PELI1-IN-1 (PELI1 inhibitor 3d) is a specific small molecule inhibitor of E3 ubiquitin ligase Pellino-1 (PELI1) with binding Kd of 8.2 uM in fluorescence quenching assays, interrupts the interaction of PELI1 and SNAIL/SLUG. |
| PC-26546 |
FB231
Parkin activator
|
FB231 is a small molecule enhancer / activator of Parkin E3 ubiquitin ligase (PARK2) activity with EC50 of 6.75 uM in in vitro ubiquitination assay. |
| PC-26528 |
CLEO4-88
GID4 binder, ACAA1 inhibitor
|
CLEO4-88 is a molecular glue binder of CTLH E3 ligase substrate adaptor GID4 with KD of 5.6 uM, promotes GID4 interaction with the peroxisomal thiolase protein ACAA1 with EC50 of 12.5 nM in HTRF assays, inhibits the catalytic activity of ACAA1. |
| PC-26463 |
NX-1013
Cbl-b inhibitor
|
NX-1013 is a potent, specific inhibitor of Casitas B-lineage lymphoma-b (Cbl-b) E3 ubiquitin ligase with binding Kd of 0.87 nM and 3.4 nM for CBL-B and CBL, and IC50 of 0.51 nM and 1.7 nM for CBLB and CBL. |
| PC-25921 |
XZA-1
HADH activator, CBX4 inhibitor
|
XZA-1 is a specific small-molecule activator of 3-hydroxyacyl-coenzyme A dehydrogenase (HADH), suppresses CBX4 SUMO E3 ligase activity and disrupts CBX4-mediated HIF-1α transcriptional activation. |
| PC-25638 |
XMU-MP-10 TFA salt
NEDD4 inhibitor
|
XMU-MP-10 TFA salt is a potent, specific, high-affinity inhibitor of HECT-type E3 ubiquitin ligase NEDD4 with MST KD of 43.92 nM, targets the HECT domain of NEDD4, significantly and selectively inhibits NEDD4 auto-ubiquitination. |
| PC-25637 |
XMU-MP-10
NEDD4 inhibitor
|
XMU-MP-10 is a potent, specific, high-affinity inhibitor of HECT-type E3 ubiquitin ligase NEDD4 with MST KD of 43.92 nM, targets the HECT domain of NEDD4, significantly and selectively inhibits NEDD4 auto-ubiquitination. |
