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Request The Product List ofFarnesoid X Receptor (FXR) Farnesoid X Receptor (FXR)

Cat. No. Product Name Information
PC-20485

BAR502

Dual FXR/GPBAR1 agonist

BAR502 (NorECDCOH) is a potent, selective, dual farnesoid X receptor (FXR) and G-protein coupled bile acid receptor 1 (GP-BAR1, TGR5) ligand (agonist) with EC50 of 2.0 and 0.4 uM, respectively.
PC-20484

PDL103

Dual FXR/GPBAR1 antagonist

PDL103 is a potent, dual FXR/GPBAR1 antagonist with IC50 of 10 and 19 uM, respectively.
PC-38044

EDP-305

FXR agonist

EDP-305 (EDP305) is a potent, selective, nonbile acid farnesoid X receptor (FXR) agonist with EC50 of 34 nM, shows antifibrotic effect.
PC-43034

INT-767

FXR/TGR5 agonist

INT-767 (INT767) is a potent, selective, dual farnesoid X receptor (FXR) and TGR5 agonist with EC50 of 30 and 630 nM, respectively.
PC-63021

MFA-1

FXR agonist

MFA-1 (Merck FXR agonist 1) is a potent, synthetic FXR agonist with EC50 of 16.9 nM in coactivator recruitment assays, displays 500-fold more potent than CDCA.
PC-61390

Nidufexor

FXR agonist

Nidufexor (LMB763, LMB-763) is a potent, selective, non-bile acid partial agonist of farnesoid X receptor (FXR) with EC50 of 7 nM in FXR-HTRF biochemical assay measuring the ligand-induced interaction between FXR and the Steroid Receptor Coactivator-1 (SRC1).
PC-61368

Cilofexor

FXR agonist

Cilofexor (GS-9674, GS9674, PX-104) is a potent, specific, non-steroidal farnesoid X receptor (FXR) agonist with EC50 of 43 nM.
PC-61057

DM509

FXR agonist, sEH inhibitor

DM509 is a potent, orally active dual modulator of FXR and soluble epoxide hydrolase (sEH) that exertss partial FXR agonism (pEC50=7.7) and sEH inhibitory activity (pIC50=8.4).
PC-60080

GSK-2324

FXR agonist

GSK-2324 (GSK2324) is a potent, selective, full FXR agonist with EC50 of 120 nM in FRET assay.
PC-60079

LY-2562175

FXR agonist

LY-2562175 (LY2562175, LY 2562175) is a novel potent, selective, partial FXR agonist with EC50 of 193 nM.
PC-60056

Tropifexor

FXR agonist

Tropifexor (LJN-452, LJN452) is a novel highly potent, selective, orally acitive FXR full agonist with EC50 of 0.26 nM.
PC-42734

Fexaramine

FXR agonist

Fexaramine is a potent, specific FXR agonist with EC50 of 25 nM, more efficacious ligand for FXR than GW4064.

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