Welcome to ProbeChem!Global Supplier of Chemical Probes, Inhibitors & Agonists.

You are here:Home-Chemical Inhibitors & Agonists-Nuclear Receptor/Transcription Factor-Farnesoid X Receptor (FXR)-ID166
ID166

Chemical Structure : ID166

CAS No.: 2247972-61-6

ID166 (Lecufexor, ID119031166)

Catalog No.: PC-21879Not For Human Use, Lab Use Only.

Lecufexor (D119031166, ID166) is a novel potent, selective farnesoid X receptor (FXR) agonist with EC50 of 3 nM and 5 nM in TR-FRET FXR co-activator assay and FXR reporter assay, respectively.

Packing Price Stock Quantity
50 mg Get quote
100 mg Get quote
200 mg Get quote

Bulk size, bulk discount!

Welcome credit card payment!

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    Lecufexor (D119031166, ID166) is a novel potent, selective farnesoid X receptor (FXR) agonist with EC50 of 3 nM and 5 nM in TR-FRET FXR co-activator assay and FXR reporter assay, respectively.
    ID166 induces SHP gene expression more strongly than obeticholic acid (OCA) (EC50 of 1 μM) with an EC50 value of 19 nM in human hepatocytes.
    ID166 is highly selective for FXR against a luciferase reporter assay on 19 human nuclear receptors up to 3 μM, also does not exhibit agonistic activities on either MRGPRX4 or TGR5 up to 100 μM.
    ID166 strongly increases the gene expression levels of the FXR target genes up to 14-fold in hamster liver and intestine in a dose-dependent manner, and plasma fibroblast growth factor 15 (FGF15) level is significantly increased by ID166 at a dose of 20 mg/kg/day.
    ID166 (30 mg/kg) ameliorates the NASH phenotype induced by the fed free choice diet.
    ID166 reduces total NAFLD activity and hepatic fibrosis score in NASH hamsters fed a free choice diet, modulates the relative abundance of gut microbes in NASH hamsters.

    Physicochemical Properties

    M.Wt 619.88
    Formula C32H21Cl3N2O5
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO

    Chemical Name/SMILES

    (5-((2-Chloro-4-((5-cyclopropyl-3-(2,6-dichlorophenyl)isoxazol-4-yl)methoxy)phenyl)ethynyl)-2-cyclopropylbenzo[d]oxazole-7-carboxylic acid)

    References

    1. Moon AN, et al. Biomed Pharmacother. 2024 Feb 29;173:116331.

    Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright

    Contact Us sales@probechem.com

    Bulk Inquiry

    * Indicates a Required FieldYour information is safe with us.

    • *Product name:
    • *Applicant name:
    • *Email address:
    • *Organization name:
    • *Requested quantity:
    • *Country:
    • *Additional Information:

    Get Quote

    * Indicates a Required FieldYour information is safe with us.

    • *Product name:
    • *Applicant name:
    • *Email address:
    • *Organization name:
    • *Requested quantity:
    • *Country:
    • Additional Information: