| Cat. No. |
Product Name |
Information |
| PC-22957 |
CAM2602
Aurora A-TPX2 inhibitor
|
CAM2602 is a potent, selective small molecule inhibitor of Aurora A-TPX2 protein-protein interaction (PPI), binds to Aurora A and displaces TPX2 from Aurora A with a KD of 19 nM, |
| PC-22141 |
DBPR728
Aurora A inhibitor
|
DBPR728 is an oral bioavailable acyl-based prodrug of 6K465, which is a potent selective Aurora A (AURKA) inhibitor, effectively inhibits cancer cells overexpressing c-MYC- and/or N-MYC. |
| PC-20713 |
LXY18
AURKB inhibitor
|
LXY18 is a potent orally available blocker of AURKB relocation in mitosis with minimum effective concentration (MEC) of 3.5 nM for inducing polyploidy, shows broad-spectrum growth inhibitory and apoptosis-inducing activities with low nanomolar potencies. |
| PC-49273 |
PF-03814735
Aurora inhibitor
|
PF-03814735 is a potent, orally bioavailable, reversible inhibitor of both Aurora A and Aurora B kinases with IC50 values of 0.8 and 5 nM, respectively. |
| PC-38795 |
PHA-680626
Aurora Kinase inhibitor
|
PHA-680626 is a kinase inhibitor exhibiting strong inhibitory activity on both Bcr-Abl and Aurora kinases, also inhibits the formation of the Aurora-A/N-Myc complex. |
| PC-73448 |
Tinengotinib
Multikinase inhibitor
|
Tinengotinib (TT-00420) is a spectrum-selective multikinase inhibitor that targets cell proliferation, angiogenesis, and immunomodulatory pathways by inhibiting Aurora A/B and JAK involved in cytokine signalling, and RTKs involved in angiogenesis (FGFRs and VEGFRs). |
| PC-73347 |
F114
Aurora/LIMK inhibitor
|
F114 is a novel, first-in-class, dual aurora and lim kinase (LIMK) inhibitor with IC50 of 72 nM and 137 nM against Aurora-A and Limk1, respectively, F114 inhibits GBM proliferation and invasion. |
| PC-72439 |
TAS-119
Aurora A inhibitor
|
TAS-119 (TAS119) is a potent, selective, orally active inhibitor of Aurora A with IC50 of 1 nM. |
| PC-35756 |
LY3295668
Aurora A inhibitor
|
LY3295668 (LY-3295668, AK-01) is a novel potent, highly selective, orally active Aurora-A kinase inhibitor with Ki of 0.8 nM, H446 AurA auto-P IC50 of 0.6 nM. |
| PC-43432 |
AMG-900
Aurora kinases inhibitor
|
AMG-900 (AMG900) is a potent, highly selective, orally bioavailable pan-Aurora kinase inhibitor with IC50 of 5, 4 and 1 nM for Aurora A, B and C, respectively. |
| PC-43431 |
MK-5108
Aurora A inhibitor
|
MK-5108 (VX-689) is a potent, highly selective Aurora-A kinase inhibitor with IC50 of 0.064 nM. |
| PC-63253 |
BI 831266
AURKB inhibitor
|
BI 831266 is a potent, selective inhibitor of Aurora kinase B (AURKB) with IC50 of binding IC50 of 42 nM. |
