| Cat. No. |
Product Name |
Information |
| PC-73347 |
F114
Aurora/LIMK inhibitor
|
F114 is a novel, first-in-class, dual aurora and lim kinase inhibitor with IC50 of 72 nM and 137 nM against Aurora-A and Limk1, respectively, F114 inhibits GBM proliferation and invasion. |
| PC-72439 |
TAS-119
Aurora A inhibitor
|
TAS-119 (TAS119) is a potent, selective, orally active inhibitor of Aurora A with IC50 of 1 nM. |
| PC-35756 |
LY3295668
Aurora A inhibitor
|
LY3295668 (LY-3295668, AK-01) is a novel potent, highly selective, orally active Aurora-A kinase inhibitor with Ki of 0.8 nM, H446 AurA auto-P IC50 of 0.6 nM. |
| PC-43432 |
AMG-900
Aurora kinases inhibitor
|
AMG-900 (AMG900) is a potent, highly selective, orally bioavailable pan-Aurora kinase inhibitor with IC50 of 5, 4 and 1 nM for Aurora A, B and C, respectively. |
| PC-43431 |
MK-5108
Aurora A inhibitor
|
MK-5108 (VX-689) is a potent, highly selective Aurora-A kinase inhibitor with IC50 of 0.064 nM. |
| PC-63253 |
BI 831266
AURKB inhibitor
|
BI 831266 is a potent, selective inhibitor of Aurora kinase B (AURKB) with IC50 of binding IC50 of 42 nM. |
| PC-42348 |
ZM-447439
Aurora A/B inhibitor
|
ZM-447439 is a potent, selective dual Aurora A and Aurora B inhibitor with IC50 of 110 and 130 nM, respectively. |
| PC-42868 |
Hesperadin
Aurora B inhibitor
|
Hesperadin is a small molecule Aurora B inhibitor (IC50=250 nM) that perturbs mitosis and induces polyploidy, causes mammalian cells to enter anaphase in the presence of monooriented chromosomes. |
| PC-42864 |
CCT129202
Aurora Kinase inhibitor
|
CCT129202 is a potent, selective, ATP-competitive pan-Aurora kinase inhibitor with IC50 of 42, 198 and 227 nM for Aurora A, Aurora B and Aurora C, respectively. |
| PC-42820 |
SNS-314
Aurora Kinase inhibitor
|
SNS-314 is a potent, selective pan-Aurora kinase inhibitor with IC50 of 9 and 31 nM for Aurora A and Aurora B, repectively. |
| PC-62560 |
AS 703569
Aurora kinases inhibitor
|
Cenisertib (AS 703569;R763) is a novel potent, orally available inhibitor of Aurora kinases, exhibits signifficant anti-proliferative activity against a wide range of tumor cells both in vitro and in vivo (A549 EC50=9 nM). |
| PC-61954 |
BPR1K653 hydrochloride
Aurora A/B inhibitor
|
BPR1K653 hydrochloride isa potent Aurora kinase inhibitor that inhibits Aurora-A and Aurora-B with IC50 of 24 nM and 45 nM, respectively. |
