| Cat. No. |
Product Name |
Information |
| PC-24004 |
AAPK-25
DLGAP5 inhibitor
|
AAPK-25 is a small molecule inhibitor of DLGAP5 with a binding energy of −9.2 Kcal/mol, suppresses proliferation of PRAD cells via inhibiting DLGAP5/E2F1 axis, also is a potent, dual Aurora/PLK coinhibitor. |
| PC-22957 |
CAM2602
Aurora A-TPX2 inhibitor
|
CAM2602 is a potent, selective small molecule inhibitor of Aurora A-TPX2 protein-protein interaction (PPI), binds to Aurora A and displaces TPX2 from Aurora A with a KD of 19 nM, |
| PC-22868 |
MK-8745
Aurora A inhibitor
|
MK-8745 (MK8745) is a potent, specific Aurora kinase A (Aurora A, AURKA) inhibitor with IC50 of 0.6 nM, induces apoptotic cell death in a p53-dependent manner. |
| PC-22152 |
JAB-2485
Aurora A inhibitor
|
JAB-2485 is a potent, highly selective small-molecule Aurora kinase A (AURKA) inhibitor with IC50 of 0.33 nM, with >1500-fold selectivity over AURKB and AURKC. |
| PC-22141 |
DBPR728
Aurora A inhibitor
|
DBPR728 is an oral bioavailable acyl-based prodrug of 6K465, which is a potent selective Aurora A (AURKA) inhibitor, effectively inhibits cancer cells overexpressing c-MYC- and/or N-MYC. |
| PC-22139 |
6K465
Aurora A inhibitor
|
6K465 is a potent selective Aurora A (AURKA) inhibitor, effectively inhibits cancer cells overexpressing c-MYC- and/or N-MYC. |
| PC-21560 |
Reversine
Aurora Kinase inhibitor
|
Reversine is a potent, ATP-competitive Aurora kinases inhibitor with IC50 of 400, 500 and 400 nM for Aurora A, Aurora B and Aurora C, respectively. |
| PC-21147 |
Ilorasertib
Aurora Kinase inhibitor
|
Ilorasertib (ABT-348) is a potent inhibitor of Aurora kinases as well as the VEGF and PDGF families of receptor tyrosine kinases (Aur B IC50=2 nM, PDGFRβ IC50=3 nM). |
| PC-20713 |
LXY18
AURKB inhibitor
|
LXY18 is a potent orally available blocker of AURKB relocation in mitosis with minimum effective concentration (MEC) of 3.5 nM for inducing polyploidy, shows broad-spectrum growth inhibitory and apoptosis-inducing activities with low nanomolar potencies. |
| PC-49273 |
PF-03814735
Aurora inhibitor
|
PF-03814735 is a potent, orally bioavailable, reversible inhibitor of both Aurora A and Aurora B kinases with IC50 values of 0.8 and 5 nM, respectively. |
| PC-38795 |
PHA-680626
Aurora Kinase inhibitor
|
PHA-680626 is a kinase inhibitor exhibiting strong inhibitory activity on both Bcr-Abl and Aurora kinases, also inhibits the formation of the Aurora-A/N-Myc complex. |
| PC-73448 |
Tinengotinib
Multikinase inhibitor
|
Tinengotinib (TT-00420) is a spectrum-selective multikinase inhibitor that targets cell proliferation, angiogenesis, and immunomodulatory pathways by inhibiting Aurora A/B and JAK involved in cytokine signalling, and RTKs involved in angiogenesis (FGFRs and VEGFRs). |
