| Cat. No. |
Product Name |
CAS No. |
Information |
| PC-70174 |
CEP-1347
|
156177-65-0 |
CEP-1347 (KT-7515) is a potent and selective MLK inhibitor that completely rescues motoneurons and inhibits JNK1 activation with IC50 of 20 nM. |
| PC-43118 |
URMC-099
|
1229582-33-5 |
URMC-099 is a potent, orally bioavailable, brain penetrant inhibitor of mixed lineage kinase 3 (MLK3) with IC50 of 14 nM. |
| PC-70325 |
GW 806742X
|
579515-63-2 |
A small molecule MLKL (Mixed Lineage Kinase Domain-Like) interactor that binds the MLKL pseudokinase domain (Kd=9.3 uM), retards membrane association to inhibit necroptosis. |
| PC-70175 |
M-443
|
1820684-31-8 |
A specific, irreversible inhibitor of MLK-related kinase MRK (ZAK), does not inhibit Bcr-Abl. |
| PC-42202 |
Necrosulfonamide
|
1360614-48-7 |
A small molecule covalent inhibitor of mixed lineage kinase domain like protein (MLKL) that specifically blocks necrosis downstream of RIP3 activation. |
