| Cat. No. |
Product Name |
Information |
| PC-21158 |
TC13172
MLKL inhibitor
|
TC13172 (TC 13172) is a highly potent necroptosis inhibitor targeting the mixed lineage kinase domain-like protein (MLKL), inhibits necroptosis with IC50 of 2 nM in TSZ-induced necroptosis assays in HT-29 cells. |
| PC-20851 |
KC-130
ZAK inhibitor
|
KC-130 (KC130, ZAK inhibitor 8) is a potent, selective and covalent leucine-zipper and sterile-α motif kinase (ZAK) inhibitor with IC50 of 11.5 nM. |
| PC-43118 |
URMC-099
MLK3 inhibitor
|
URMC-099 is a potent, orally bioavailable, brain penetrant inhibitor of mixed lineage kinase 3 (MLK3) with IC50 of 14 nM. |
| PC-70325 |
GW 806742X
MLKL inhibitor, PINK1-Parkin activator
|
GW 806742X (T0446) is a small molecule MLKL (Mixed Lineage Kinase Domain-Like) interactor that binds the MLKL pseudokinase domain (Kd=9.3 uM), retards membrane association to inhibit necroptosis. |
| PC-70175 |
M443
ZAK inhibitor
|
M443 (M 443) is a specific, irreversible inhibitor of MLK-related kinase MRK (ZAK), does not inhibit Bcr-Abl. |
| PC-70174 |
CEP1347
MLK inhibitor
|
CEP1347 (KT7515) is a potent and selective mixed lineage kinase (MLK) inhibitor that completely rescues motoneurons and inhibits JNK1 activation with IC50 of 20 nM. |
| PC-42202 |
Necrosulfonamide
MLKL inhibitor, GSDMD inhibitor
|
Necrosulfonamide is a small molecule covalent inhibitor of mixed lineage kinase domain like protein (MLKL) that specifically blocks necrosis downstream of RIP3 activation. |
| PC-24410 |
BI-8925
MLKL inhibitor
|
BI-8925 is a potent, selective and covalent inhibitor of mixed lineage kinase domain-like (MLKL), inhibits necroptosis in Jurkat and U937 cells with an IC50 of 541 and 271 nM, respectively. |
| PC-24409 |
MBA-h1
MLKL inhibitor
|
MBA-h1 is a specific small molecule inhibitor of human mixed lineage kinase domain-like (MLKL), targets the Hc/groove of human MLKL, inhibits necroptosis in human WT HT-29 and HeLa-hRIPK3 knockin cells. |
| PC-24408 |
MBA-m1
MLKL inhibitor
|
MBA-m1 is a specific small molecule inhibitor of mouse mixed lineage kinase domain-like (MLKL), targets the Hc/groove of mouse MLKL, delays necroptosis in mouse WT NIH-3T3 cells. |
| PC-23625 |
CLFB-1134
MLK3 inhibitor
|
CLFB-1134 is a potent, specific and brain-penetrant inhibitor of mixed lineage kinase-3 (MLK3) with IC50 of 42 nM. |
| PC-23623 |
MLK3 inhibitor 37
MLK3 inhibitor
|
MLK3 inhibitor 37 is a potent, selective mixed-lineage protein kinase 3 (MLK3, MAP3K11)inhibitor with IC50 of <1 nM, exhibiting kinome-wide selectivity. |
