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Cat. No. Product Name Information
PC-22623

KHKI-01215

NUAK2 inhibitor

KHKI-01215 is a highly potent NUAK family kinase 2 (NUAK2) inhibitor with IC50 of 52 nM.
PC-22622

KHKI-01128

NUAK2 inhibitor

KHKI-01128 is a highly potent NUAK family kinase 2 (NUAK2) inhibitor with IC50 of 24 nM.
PC-20481

Metformin

AMPK activator

Metformin (1,1-Dimethylbiguanide) is a traditional anti-diabetic drug, functions by inhibiting complex I in the mitochondrial respiratory chain, activates AMPK and enhances insulin sensitivity.
PC-20473

RX-375

AMPK activator

RX-375 (RX375) is an indirect small-molecule activator of AMPK by directly binds to Prohibitins (PHB1 and PHB2), induces dissociation of AMPK-PHBs complex.
PC-20056

BI-9774

AMPK activator

BI-9774 (BI 9774) is a potent pan-AMPK activator with EC50 of 64 nM in an ADP-Glo kinase assay with human AMPK (α1β1γ1) and EC50 of 8 nM in a cellular GLUT4 translocation assay.
PC-47031

KI-301670

NUAK1 inhibitor

KI-301670 is a novel potent, specific NUAK1 inhibitor, disturbs NUAK1 signaling by targeting its ATP binding site, effectively inhibits the PI3K/AKT pathway in pancreatic cancer cells.
PC-47024

PXL770

AMPK activator

PXL770 is a novel orally bioavailable, small-molecule direct AMPK activator with EC50 of 16.2, 42.1 and 64 nM for α1β1γ1, α1β1γ2 and α1β1γ3, directly increases AMPK activity by both allosteric activation and protection from dephosphorylation.
PC-47019

RSVA405

AMPK activator

RSVA405 is a small-molecule activator of AMPK, facilitates CaMKKβ-dependent activation of AMPK, inhibits mTOR and promotes autophagy to increase Aβ degradation by the lysosomal system with EC50 of 1 uM.
PC-38664

MSG011

pan AMPK activator

MSG011 is a potent, pan AMPK isoform activator with EC50 of 140.4 nM, 248.9 nM, 553.4 nM, and 472.9 nM for α1β1γ1, α1β2γ1, α2β1γ1, and α2β2γ1, respectively.
PC-38551

IMM-H007

AMPK activator

IMM-H007 (H007, WS070117) is a novel lipid-lowering agent and AMPK activator, reduces serum lipid levels and inhibits lipid accumulation both in vitro and in vivo.
PC-38548

Debio 0930

AMPK activator

Debio 0930 (MY 63-78) is a specific and potent direct AMPK activator, allosterically activates AMPK activity in prostate cancer cells with EC50 of 25 uM, without altering the energy levels.
PC-73284

HTH-02-006

NUAK2 inhibitor

HTH-02-006 is a potent, selective reversible inhibitor of NUAK1/2 with binding IC50 of 8/126 nM, respectively.

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