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KHKI-01215

Chemical Structure : KHKI-01215

CAS No.:

KHKI-01215 (KHKI 01215)

Catalog No.: PC-22623Not For Human Use, Lab Use Only.

KHKI-01215 is a highly potent NUAK family kinase 2 (NUAK2) inhibitor with IC50 of 52 nM.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

KHKI-01215 is a highly potent NUAK family kinase 2 (NUAK2) inhibitor with IC50 of 52 nM.
KHKI-01128 suppresses cell proliferation IC50 of 3.16 μM, and induces apoptosis of SW480 cells.
KHKI-01128 effectively suppresses the expression of YES1-associated transcriptional regulator (YAP) target genes.

Physicochemical Properties

M.Wt 598.41
Formula C24H26F3IN6O
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

4-(3-(dimethylamino)phenoxy)-5-iodo-N-(4-(4-methylpiperazin-1-yl)-3-(trifluoromethyl)phenyl)pyrimidin-2-amine

References

1. Seung Hyeong Lee, et al. Anticancer Res. 2024 Jul;44(7):2909-2919.

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