| Cat. No. |
Product Name |
Information |
| PC-22068 |
NIBR-LTSi
Lats kinases inhibitor
|
NIBR-LTSi is a potent, highly selective and orally active LATS kinase inhibitor with IC50 of 1.4 nM in biochemical CALIPER assay, potently reduces pYAP levels with IC50 of 2.16 uM in JHH5 cells. |
| PC-49294 |
IHMT-MST1-58
MST1 inhibitor
|
IHMT-MST1-58 is a potent, selective inhibitor of STE20-like protein 1 kinase (MST1) with IC50 value of 23 nM. |
| PC-49207 |
TRULI
Lats kinases inhibitor
|
TRULI is a small molecule Yap signaling activator, acts as an ATP-competitive inhibitor of Lats kinases in vitro (Lats1 kinase, IC50=0.2 nM, 10 uM ATP), prevents Yap phosphorylation in the cell-based assays with EC50 of 510 nM. |
| PC-49206 |
TDI-011536
Lats kinases inhibitor
|
TDI-011536 is a potent, ATP-competitive inhibitor of Lats kinases with IC50 of 0.76 nM (2 mM ATP) in vitro assays, prevents Yap phosphorylation in the cell-based assays with EC50 of 10 nM. |
| PC-73093 |
GA-017
LATS kinase inhibitor
|
GA-017 (GA017) is a potent, selective, ATP-competitive LATS kinase (LATS1/2) inhibitor with IC50 of 4.10/3.92 nM, respectively, promotes cell growth. |
| PC-72700 |
SBP-3264
STK3/4 inhibitor
|
SBP-3264 (SBP3264) is a sepecific inhibitor of Hippo signaling pathway kinases STK3 and STK4 with low nanomolar potency. |
| PC-38111 |
VT02484
LATS inhibitor
|
VT02484 is the negative control compound of VT02956, which is a highly potent Hippo pathway kinase LATS inhibitor.. |
| PC-38110 |
VT02956
LATS inhibitor
|
VT02956 is a potent, specific inhibitor of Hippo pathway kinase LATS with IC50 of 0.76 nM (LATS1) and 0.52 nM (LATS2), respectively. |
| PC-42188 |
XMU-MP-1
MST1/2 inhibitor
|
XMU-MP-1 is a potent, selective, and ATP-competitive inhibitor of the mammalian Hippo orthologs, Sterile 20-like kinases MST1 and MST2 with IC50 of 71.1 nM and 38.1 nM, respectively. |
| PC-21957 |
mCLC846
MST1/2 inhibitor
|
mCLC846 is a small molecule, orally bioavailable serine/threonine kinase 4/3 (MST1/2) inhibitor with IC50 of 26.3 nM and 214 nM for MST1 and MST2, respectively. |
| PC-21869 |
UNC-BE4-017
STK3 inhibitor
|
UNC-BE4-017 is a selective STK3 small-molecule inhibitor, also potently inhibits JAK1, JAK2, and JAK3, but not other kinases in a panel of 48 kinases. |
| PC-21868 |
UNC-SOB-5-16
STK3 inhibitor
|
UNC-SOB-5-16 is a potent, selective STK3 small-molecule inhibitor with IC50 of 22 nM, also inhibits LRRK2. |
