MST3/4 inhibitor MR24

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Chemical Structure : MST3/4 inhibitor MR24

Catalog No.: PC-21861Not For Human Use, Lab Use Only.

MST3/4 inhibitor MR24 is a potent, selective STE20-like (MST3/4) kinase inhibitor with IC50 of 57 nM and 583 nM for MST3 and MST4, respectively.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

MST3/4 inhibitor MR24 is a potent, selective STE20-like (MST3/4) kinase inhibitor with IC50 of 57 nM and 583 nM for MST3 and MST4, respectively.
MR24 does not inhibit MST1/2, and selectivity score with 8/100 kinases, also only weakly binds to NEK2, CK1e, and FES, with EC50 values in the micromolar range
MR24 increases the fraction of cells in the G1 phase at 10 μM in HCT116 cells.
MR24 inhibits Hippo signaling pathway and mitotic cell-cycle progression.

Physicochemical Properties

M.Wt	509.01
Formula	C26H29ClN6O3
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	8-(4-Aminobutyl)-6-(2-chloro-4-(6-methylpyridin-2-yl)phenyl)-2-((1,3-dihydroxypropan-2-yl)amino)pyrido[2,3-d]pyrimidin-7(8H)-one

References

1. Marcel Rak, et al. J Med Chem. 2024 Feb 29. doi: 10.1021/acs.jmedchem.3c02217.

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