| Cat. No. |
Product Name |
CAS No. |
Information |
| PC-35856 |
UBCS039
|
358721-70-7 |
UBCS039 (UBCS-039) is the first synthetic activator of the NAD+-dependent protein lysine deacetylase SIRT6 with EC50 of 38 uM. |
| PC-35760 |
MDL-800
|
2275619-53-7 |
MDL-800 (MDL800) is a first-in-class, selective, cellular active SIRT6 allosteric activator, increases SIRT6 deacetylation activity with EC50 of 10.3 uM in RHKK-ac-AMC and FDL assays. |
| PC-63242 |
MC3482
|
|
MC3482 is a potent, specific SIRT5 inhibitor, increases the ammonia content in cells leading to autophagy and mitophagy, shows selective SIRT5 inhibition vs SIRT1-3.. |
| PC-60123 |
SirReal2
|
1848251-24-0 |
SirReal2 (MZ25) is a novel potent, selective Sirt2 inhibitor with IC50 of 0.435 uM. |
| PC-49474 |
SCIC2.1
|
923763-29-5 |
SCIC2.1 is a potent small molecule SIRT1 activator (175%, AC50=36.8 uM), directly binds SIRT1 and protects SIRT1 from thermal degradation. |
| PC-49248 |
JYQ-42
|
|
JYQ-42 is a potent, selective SIRT6 allosteric inhibitor, effectively inhibits SIRT6 deacetylation with IC50 of 2.33 uM, inhibits the deacetylation activity of SIRT6 in pancreatic cancer cell lines. |
| PC-49081 |
MC3138
|
|
MC3138 is a potent and selective small-molecule SIRT5 activator, inhibits proliferation in SIRT5-low PDAC cell lines and organoids. |
