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Cat. No. Product Name CAS No. Information
PC-38277

BSJ-04-122

2513289-74-0 BSJ-04-122 is a potent, selective, covalent dual MKK4/7 inhibitor with IC50 of 4/181 nM, displays excellent kinome selectivity.
PC-43380

Cobimetinib R-enantiomer

934660-94-3 Cobimetinib R-enantiomer (GDC-0973.
PC-43369

Cobimetinib

934660-93-2 Cobimetinib (GDC-0973, XL-518) is a potent, selective MEK inhibitor with IC50 of 4.2 nM for MEK1.
PC-42857

AS703026

1236699-92-5 AS703026 (Pimasertib, MSC1936369B) is a potent, selective, allosteric, orally bioavailable MEK1/2 inhibitor, inhibits the growth of MM cell lines with IC50 of 0.005-2 uM.
PC-62664

Vacquinol-1

5428-80-8 Vacquinol-1 (NSC 13316) is a MKK4 (MAP2K4, MEK4) activator that induces vacuolization, induces ATP depletion in glioblastoma cells (IC50 = 3.14 uM) without affecting fibroblasts, embryonic stem cells, or osteosarcoma cells.
PC-45504

RO-5126766

946128-88-7 RO-5126766 (CH-5126766, Avutometinib) is a potent, first-in-class dual Raf/MEK inhibitor with IC50 of 56 nM/160 nM for C-Raf/MEK1.
PC-20026

Darizmetinib

2369583-33-3 Darizmetinib is a potent, selective inhibitor of MKK4 (MAP2K4/SEK1), shows potential for promoting liver regeneration or reducing or preventing hepatocyte death.

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