| Cat. No. |
Product Name |
CAS No. |
Information |
| PC-38277 |
BSJ-04-122
|
2513289-74-0 |
BSJ-04-122 is a potent, selective, covalent dual MKK4/7 inhibitor with IC50 of 4/181 nM, displays excellent kinome selectivity. |
| PC-43380 |
Cobimetinib R-enantiomer
|
934660-94-3 |
Cobimetinib R-enantiomer (GDC-0973. |
| PC-43369 |
Cobimetinib
|
934660-93-2 |
Cobimetinib (GDC-0973, XL-518) is a potent, selective MEK inhibitor with IC50 of 4.2 nM for MEK1. |
| PC-42857 |
AS703026
|
1236699-92-5 |
AS703026 (Pimasertib, MSC1936369B) is a potent, selective, allosteric, orally bioavailable MEK1/2 inhibitor, inhibits the growth of MM cell lines with IC50 of 0.005-2 uM. |
| PC-62664 |
Vacquinol-1
|
5428-80-8 |
Vacquinol-1 (NSC 13316) is a MKK4 (MAP2K4, MEK4) activator that induces vacuolization, induces ATP depletion in glioblastoma cells (IC50 = 3.14 uM) without affecting fibroblasts, embryonic stem cells, or osteosarcoma cells. |
| PC-45504 |
RO-5126766
|
946128-88-7 |
RO-5126766 (CH-5126766, Avutometinib) is a potent, first-in-class dual Raf/MEK inhibitor with IC50 of 56 nM/160 nM for C-Raf/MEK1. |
| PC-20026 |
Darizmetinib
|
2369583-33-3 |
Darizmetinib is a potent, selective inhibitor of MKK4 (MAP2K4/SEK1), shows potential for promoting liver regeneration or reducing or preventing hepatocyte death. |
