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Chemical Structure : HRX-0233
Catalog No.: PC-21799Not For Human Use, Lab Use Only.
HRX-0233 (HRX0233) is a potent, selective MAP2K4 (MKK4) inhibitor, HRX-0233 is synergistic with RAS inhibitors in KRAS-mutant cancers.
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HRX-0233 (HRX0233) is a potent, selective MAP2K4 (MKK4) inhibitor, HRX-0233 is synergistic with RAS inhibitors in KRAS-mutant cancers.
Combination of sotorasib, a drug targeting KRASG12C, and the MAP2K4 inhibitor HRX-0233 prevents this feedback activation and is highly synergistic in a panel of KRASG12C-mutant lung and colon cancer cells.
Combining HRX-0233 and sotorasib is well-tolerated and resulted in durable tumor shrinkage in mouse xenografts of human lung cancer cells.
HRX-0233 combined with MEK inhibition suppresses tumor growth without toxicity in a H2122 xenograft model.
| M.Wt | 497.52 | |
| Formula | C24H21F2N5O3S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Robin A Jansen, et al. Proc Natl Acad Sci U S A. 2024 Feb 27;121(9):e2319492121.
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