| Cat. No. |
Product Name |
Information |
| PC-23812 |
DS79932728
G9a/GLP inhibitor
|
DS79932728 is a potent and orally bioavailable histone lysine methyltransferase EHMT2/1 (G9a/GLP) inhibitor with IC50 of 12.6/75.7 nM respectively. |
| PC-23026 |
NSD2 inhibitor 42
NSD2 inhibitor
|
NSD2 inhibitor 42 (W4275) is a potent, selective inhibitor of histone lysine methyltransferase NSD2 with IC50 of 17 nM. |
| PC-22670 |
Thiol methyltransferase inhibitor DCMB
METTL7A inhibitor
|
Thiol methyltransferase inhibitor DCMB is a small moelcule inhibitor of thiol methyltransferase (TMT) with IC50 of 1.17 uM for METTL7A (TMT1A). |
| PC-22438 |
DF-A7
YTHDF2 inhibitor
|
DF-A7 a specific small-molecule degrader/inhibitor of m6A reader YTHDF2 with IC50 of 50 nM in immunoblotting assays (HEK 293T cells), induces degradation of YTHDF2 without affecting the degradation of YTHDF1 and YTHDF3. |
| PC-22432 |
MS152
EHMT2/G9a inhibitor
|
MS152 is a potent, selective and brain penetrant EHMT2/G9a inhibitor with biochemical IC50 of 126 nM/76 nM, respectively. |
| PC-22135 |
AMG193
PRMT5 inhibitor
|
AMG193 (AMG-193) is a potent, selective and MTA-cooperative PRMT5 inhibitor with IC50 of 107 nM in MTAP deleted cells, binds to the PRMT5-MTA complex with an extremely high affinity (3.9 pM). |
| PC-22132 |
TNG908
PRMT5 inhibitor
|
TNG908 (TNG-908) is a potent, selective, brain penetrant, MTA-cooperative PRMT5 inhibitor with IC50 of 9 nM in SDMA in-cell western assay, binds the PRMT5·MTA complex, selectively kills MTAP-deleted (MTAP-null) cells. |
| PC-21974 |
Bleximenib oxalate
menin-KMT2A inhibitor
|
Bleximenib oxalate (JNJ-75276617 oxalate) is a potent, selective and orally bioavailable protein-protein interaction inhibitor of the binding between menin and KMT2A, binds to the menin protein with IC50 of 0.1 nM (human menin) in FITC assays. |
| PC-21973 |
JNJ-75276617
menin-KMT2A inhibitor
|
JNJ-75276617 (Bleximenib) is a potent, selective and orally bioavailable protein-protein interaction inhibitor of the binding between menin and KMT2A, binds to the menin protein with IC50 of 0.1 nM (human menin) in FITC assays. |
| PC-21950 |
GSK343
EZH2 inhibitor
|
GSK343 is a highly potent, selective, SAM-competitive, and cell-active EZH2 inhibitor with IC50 of 4 nM and Kiapp of 1.2 nM. |
| PC-21857 |
BI-9321 trihydrochloride
NSD3 inhibitor
|
BI-9321 (BI 9321) trihydrochloride is a potent, selective and cellular active inhibitor of the NSD3-PWWP1 domain with SPR Kd of 166 nM. |
| PC-21842 |
GSK3368715 dihydrochloride
Type 1 PRMT inhibitor
|
GSK3368715 (EPZ019997, GSK-3368715) dihydrochloride is a potent, reversible and SAM uncompetitive type I PRMT inhibitor with Kiapp of 1.5 to 81 nM for PRMT1, 3, 4, 6, and 8. |
