| Cat. No. |
Product Name |
CAS No. |
Information |
| PC-73322 |
EZM0414
|
2411748-50-8 |
EZM 0414 is a potent, selective and orally bioavailable inhibitor of histone methyltransferase SETD2 with biochemical IC50 of 18 nM, >10,000-fold selectivity over other HMTases. |
| PC-72793 |
SNDX5613
|
2169919-21-3 |
Revumenib (SNDX-5613) is a potent and selective inhibitor of menin-MLL binding with Ki of 0.149 nM. |
| PC-72620 |
PF-06821497
|
1844849-10-0 |
PF-06821497 (PF 06821497) is a potent, selective, orally bioavailable Enhancer of Zeste Homolog 2 (EZH2) inhibitor with Ki of <1 nM against Y641N mutant. |
| PC-72444 |
JNJ-64619178
|
2086772-26-9 |
JNJ-64619178 (Onametostat, JNJ 64619178) is a selective, and potent PRMT5 inhibitor with Kiapp of 0.77 nM, inhibits the PRMT5/MEP50 complex impairing cancer cell proliferation. |
| PC-72299 |
NSD1 inhibitor BT5
|
2351225-46-0 |
NSD1 inhibitor BT5 is a covalent, small molecule inhibitor of NSD1 histone methyltransferase with IC50 of 1.4 uM, shows no covalent binding to NSD2. |
| PC-38300 |
MS1943
|
2225938-17-8 |
MS1943 (MS-1943) is a first-in-class, orally bioavailable EZH2 selective degrader that effectively reduces EZH2 levels in cells, inhibits EZH2 methyltransferase activity with IC50 of 120 nM. |
| PC-38151 |
SHIN1
|
2146095-85-2 |
SHIN1 (RZ-2994, RZ 2994) is a folate-competitive, cell-permeable inhibitor of human SHMT1/2 with biochemical IC50 of 5/13 nM. |
