| Cat. No. |
Product Name |
Information |
| PC-24016 |
EP652
METTL3 inhibitor
|
EP652 is a potent, selective and in vivo active inhibitor of RNA methyltransferase METTL3 with IC50 of 2 nM (METTL3/14) in SPA primary assays. |
| PC-23812 |
DS79932728
G9a/GLP inhibitor
|
DS79932728 is a potent and orally bioavailable histone lysine methyltransferase EHMT2/1 (G9a/GLP) inhibitor with IC50 of 12.6/75.7 nM respectively. |
| PC-23137 |
UNC10013
SETDB1 modulator
|
UNC10013 is a potent, selective and cell-active covalent ligand/negative allosteric modulator of triple Tudor domain (3TD) of SETDB1 with TR-FRET IC50 of 57 nM, targets the Cys385 of SETDB1. |
| PC-23026 |
NSD2 inhibitor 42
NSD2 inhibitor
|
NSD2 inhibitor 42 (W4275) is a potent, selective inhibitor of histone lysine methyltransferase NSD2 with IC50 of 17 nM. |
| PC-22999 |
DOT1L R231Q inhibitor 37
DOT1L R231Q inhibitor
|
DOT1L R231Q inhibitor 37 is a first-in-class DOT1L R231Q inhibitor, inhibits proliferation of H460 cells expressing DOT1LR231Q with IC50 of 6.18 uM. |
| PC-22768 |
Enzomenib
menin-MLL inhibitor
|
Enzomenib (DSP-5336) is a potent, and orally bioavailable menin-MLL interaction inhibitor with IC50 of 1.4 nM, directly binds to the menin protein with Kd of 6 nM. |
| PC-22670 |
Thiol methyltransferase inhibitor DCMB
METTL7A inhibitor
|
Thiol methyltransferase inhibitor DCMB is a small moelcule inhibitor of thiol methyltransferase (TMT) with IC50 of 1.17 uM for METTL7A (TMT1A). |
| PC-22438 |
DF-A7
YTHDF2 inhibitor
|
DF-A7 a specific small-molecule degrader/inhibitor of m6A reader YTHDF2 with IC50 of 50 nM in immunoblotting assays (HEK 293T cells), induces degradation of YTHDF2 without affecting the degradation of YTHDF1 and YTHDF3. |
| PC-22432 |
MS152
EHMT2/G9a inhibitor
|
MS152 is a potent, selective and brain penetrant EHMT2/G9a inhibitor with biochemical IC50 of 126 nM/76 nM, respectively. |
| PC-22135 |
AMG 193
PRMT5 inhibitor
|
Anvumetostat (AMG 193, AMG-193) is a potent, selective and MTA-cooperative PRMT5 inhibitor with IC50 of 107 nM in MTAP deleted cells, binds to the PRMT5-MTA complex with an extremely high affinity (3.9 pM). |
| PC-22134 |
TNG462
PRMT5 inhibitor
|
Vopimetostat (TNG462, TNG-462) is a potent, selective, MTA-cooperative PRMT5 inhibitor, selective inhibits MTAP-deleted cancer cell lines. |
| PC-22132 |
TNG908
PRMT5 inhibitor
|
TNG908 (Ralometostat, TNG-908) is a potent, selective, brain penetrant, MTA-cooperative PRMT5 inhibitor with IC50 of 9 nM in SDMA in-cell western assay, binds the PRMT5·MTA complex, selectively kills MTAP-deleted (MTAP-null) cells. |
