| Cat. No. |
Product Name |
Information |
| PC-28173 |
TRDMT1i
TRDMT1 inhibitor
|
TRDMT1i (YW1842, YW-1842) is a potent small molecule inhibitor of RNA methyltransferase TRDMT1, blocks TRDMT1-mediated m5C formation in DNA-RNA hybrids in vitro and reduces the viability of cancer cell lines. |
| PC-28117 |
TR-07 hydrochloride
PRMT1 activator
|
PRMT1 activator TR-07 hydrochloride is a selective, cell-active PRMT1 activator with EC50 of 208.3 uM, selectively enhances the catalytic activity of PRMT1 in vitro. |
| PC-28112 |
PRMT1 activator TR-07
PRMT1 activator
|
PRMT1 activator TR-07 is a selective, cell-active PRMT1 activator with EC50 of 208.3 uM, selectively enhances the catalytic activity of PRMT1 in vitro. |
| PC-28089 |
LEM-06
NSD2 inhibitor
|
LEM-06 is a small molecule inhibitor of histone methyltransferase NSD2 with IC50 of 0.8 mM against H3K36 methylation in vitro. |
| PC-28088 |
NSD2 inhibitor PTD2
NSD2 inhibitor
|
NSD2 inhibitor PTD2 is a peptide derived from histone H4 sequence and inhibitor for the histone methyltransferase WHSC1 (Nuclear receptor-binding SET domain protein 2, NSD2, MMSET) with SPR KD of 3.0 uM, IC50 of 22 uM and 3.2 uM for NSD2 and NSD3 respectively. |
| PC-28070 |
AZD3632
Menin inhibitor
|
AZD3632 (AZD-3632) is a potent, selective and orally active second-generation menin inhibitor, disrupts the Menin-KMT2A complex, suppresses leukemogenic transcription and promotes malignant cell differentiation. |
| PC-27974 |
LC-YD17
YTHDC1 inhibitor
|
LC-YD17 is a potent, selective YTH domain-containing protein 1 (YTHDC1) inhibitor with IC50 of 107.12 nM, exhibits growth inhibitory activity in MOLM-13 and THP-1 cells with IC50 of 11.74 and 16.36 uM respectively. |
| PC-27973 |
LC-YD03
YTHDC1 inhibitor
|
LC-YD03 is a potent, selective YTH domain-containing protein 1 (YTHDC1) inhibitor with IC50 of 41.98 nM and BLI Kd of 102 nM, shows little to no activity against YTHDF1, YTHDF2, YTHDF3, and YTHDC2. |
| PC-27909 |
AL398
NSUN6 inhibitor
|
AL398 is a specific small molecule inhibitor of m5C methyltransferase NSUN6 with IC50 of 2.796 uM, shows negligible effects on the stability of other methyltransferases, including NOP2, NSUN2, and METTL3. |
| PC-27906 |
AN465
EV71 inhibitor, METTL3 inhibitor
|
AN465 (AN-465/42162872) is a potent inhibitor of Enterovirus 71 (EV71) with EC50 of 18.48 uM, effectively inhibits m6A methyltransferase METTL3 with IC50 of 1.782 uM and KD of 8.75 uM. |
| PC-27851 |
S-023-0996
EZH2/EGFR inhibitor
|
S-023-0996 is a potent, tumor cell selective, dual inhibitor of EZH2 and EGFR with IC50 of 2.41 nM and 42.18 nM respectively, inhibits tumor cell proliferation, migration and invasion in vitro with superior efficacy and safety than individual drug combinations. |
| PC-27770 |
FCD-11
SET1A/COMPASS inhibitor
|
FCD-11 is a first-in-class, selective small molecule inhibitor of histone methyltransferases COMPASS (Complex of proteins associated with Set1), specifically inhibits the H3K4me3 activity of SET1A/COMPASS and MLL1/COMPASS with IC50 of 1.32 uM and 3.26 uM. |
