| Cat. No. |
Product Name |
Information |
| PC-22089 |
ALKBH5 inhibitor TD19
ALKBH5 inhibitor
|
ALKBH5 inhibitor TD19 is a specific, covalent inhibitor of RNA demethylase ALKBH5, inhibits ALKBH5-induced demethylation with IC50 of 1.5-3 uM. |
| PC-20353 |
CBA-1
KDM3A inhibitor
|
CBA-1 is a small molecule inhibitor of Wnt signaling, specifically targets Jumonji (JmjC) domain-containing demethylase KDM3A with IC50 of 3.9 uM. |
| PC-20255 |
Bomedemstat
LSD1 inhibitor
|
Bomedemstat (IMG-7289) is a potent, selective, irreversible and orally active LSD1 (KDM1A) inhibitor, increases H3K4 and H3K9 methylation. |
| PC-49244 |
iJMJD6
JMJD6 inhibitor
|
iJMJD6 is a potent, specific small-molecule JMJD6 inhibitor that specifically binds to JMJD6 (ITC Kd=3.83 uM) and competes with α-KG and the substrate for binding, inhibits the demethylase activity of JMJD6 with IC50 of 149.6 nM. |
| PC-72834 |
JIB-04
Jumonji inhibitor
|
JIB-04 is a pan-Jumonji histone demethylase inhibitor (IC50=230-1100 nM) with epigenetic activity, also potently inhibits SARS-CoV-2 replication in Vero E6 cells with EC50 of 695 nM. |
| PC-72453 |
KDOBA67
KDM6A/B inhibitor
|
KDOBA67 is a novel cell-permeable inhibitor of H3K27 lysine demethylase KDM6A/B, inhibits TBXT expression chordoma cell lines. |
| PC-72386 |
MO-I-500
FTO inhibitor
|
MO-I-500 is a pharmacological inhibitor of FTO, inhibits purified FTO demethylase catalyzing demethylation with IC50 of 8.7 uM. |
| PC-72385 |
FTO inhibitor CS1
FTO inhibitor
|
FTO inhibitor CS1 (NSC 337766) is a potent, selective small-molecule inhibitor of m6A demethylase FTO, inhibits m6A demethylation with IC50 of 142.6 nM in vitro (cell-free) assays. |
| PC-72265 |
SKLB325
JMJD6 inhibitor
|
SKLB325 (SKLB 325) is a potential inhibitor for JMJD6 with Kd of 0.755 uM by SPR assays, biochemical IC50 of 0.78 uM. |
| PC-72259 |
TACH101
KDM4 inhibitor
|
TACH101 (Zavondemstat, QC8222, TACH 101) is a reversible, α-ketoglutarate competitive, selective and potent inhibitor of KDM4 isoforms A-D with IC50 values of 80 nM against all four isoforms. |
| PC-72226 |
FTO-04
FTO inhibitor
|
FTO-04 is a potent, selective, competitive small molecule inhibitor of m6A-RNA demethylase FTO with IC50 of 3.39 uM, 13-fold selectivity over RNA demethylase ALKBH5 (ALKBH5, IC50=39.4 uM). |
| PC-72225 |
FTO-02
FTO inhibitor
|
FTO-02 is a potent, selective, competitive small molecule inhibitor of m6A-RNA demethylase FTO with IC50 of 2.18 uM, 40-fold selectivity over RNA demethylase ALKBH5 (ALKBH5, IC50=85.5 uM). |
