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Cat. No. Product Name Information
PC-38508

GSK-J1

KDM6A/6B inhibitor

GSK-J1 is a potent, selective inhibitor of the H3K27 histone demethylases JMJD3 (KDM6B) and UTX (KDM6A) with IC50 of 28 nM and 53 nM, respectively.
PC-72834

JIB-04

Jumonji KDM inhibitor

JIB-04 is a pan-Jumonji histone demethylase inhibitor (IC50=230-1100 nM) with epigenetic activity, also potently inhibits SARS-CoV-2 replication in Vero E6 cells with EC50 of 695 nM.
PC-72453

KDOBA67

KDM6A/B inhibitor

KDOBA67 is a novel cell-permeable inhibitor of H3K27 lysine demethylase KDM6A/B, inhibits TBXT expression chordoma cell lines.
PC-72386

MO-I-500

FTO inhibitor

MO-I-500 is a pharmacological inhibitor of FTO, inhibits purified FTO demethylase catalyzing demethylation with IC50 of 8.7 uM.
PC-72385

FTO inhibitor CS1

FTO inhibitor

FTO inhibitor CS1 (Bisantrene, NSC 337766) is a potent, selective small-molecule inhibitor of m6A demethylase FTO, inhibits m6A demethylation with IC50 of 142.6 nM in vitro (cell-free) assays.
PC-72265

SKLB325

JMJD6 inhibitor

SKLB325 (SKLB 325) is a potential inhibitor for JMJD6 with Kd of 0.755 uM by SPR assays, biochemical IC50 of 0.78 uM.
PC-72264

JMJD7 inhibitor compound 3 (Cpd-3)

JMJD7 inhibitor

JMJD7 inhibitor compound 3 (Cpd-3) is the first small molecule inhibitor of JMJD7 with IC50 of 6.62 uM, efficiently bind to JMJD7 in vitro, displays good inhibitory activity against cancer cell lines expressing a high level of JMJD7.
PC-72263

MINA53 inhibitor 10

MINA53 inhibitor

MINA53 inhibitor 10 is a first in class, potent, selective MINA53 inhibitor with IC50 of 1.5 uM, selective over NO66, KDM4-6 and other JmjC oxygenases.
PC-72262

MINA53 inhibitor 9

MINA53 inhibitor

MINA53 inhibitor 9 is a first in class, potent, selective MINA53 inhibitor with IC50 of 1.6 uM, selective over NO66, KDM4-6 and other JmjC oxygenases.
PC-72259

TACH101

KDM4 inhibitor

TACH101 (Zavondemstat, QC8222, TACH 101) is a reversible, α-ketoglutarate competitive, selective and potent inhibitor of KDM4 isoforms A-D with IC50 values of 80 nM against all four isoforms.
PC-72226

FTO-04

FTO inhibitor

FTO-04 is a potent, selective, competitive small molecule inhibitor of m6A-RNA demethylase FTO with IC50 of 3.39 uM, 13-fold selectivity over RNA demethylase ALKBH5 (ALKBH5, IC50=39.4 uM).
PC-72225

FTO-02

FTO inhibitor

FTO-02 is a potent, selective, competitive small molecule inhibitor of m6A-RNA demethylase FTO with IC50 of 2.18 uM, 40-fold selectivity over RNA demethylase ALKBH5 (ALKBH5, IC50=85.5 uM).

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