| Cat. No. |
Product Name |
Information |
| PC-23163 |
P3FI-63
KDM3B inhibitor
|
P3FI-63 is a small molecule PAX3-FOXO1 activity inhibitor, blocks PAX3-FOXO1 downstream target gene expression, inhibits multiple KDMs including KDM3B, KDM4B, KDM5A, and KDM6B, with highest potency against KDM3B (IC50=7 uM). |
| PC-22985 |
YTH domain inhibitor N-7
m6A YTH domain inhibitor
|
YTH domain inhibitor N-7 is a specific small molecule, pan-inhibitor of YTH domain-containing m6A RNA readers with IC50 of 30-48 uM for human YTHDF1, YTHDF2, YTHDF3, YTHDC1, and YTHDC2 proteins. |
| PC-22960 |
ML234
EZH2/LSD1 inhibitor
|
ML234 is a potent EZH2/LSD1 dual inhibitor with IC50 of 0.09/0.12 uM respectively, shows excellent antiproliferative capacity against prostate cancer cell lines LNCAP, PC3, and 22RV1. |
| PC-22951 |
GSK-J5
|
GSK-J5 is the ethyl ester pro-drug of GSK-J2, which lacks H3K27 demethylase activity as a inactive control molecule for GSK-J4. |
| PC-22847 |
FTO inhibitor FB23
FTO inhibitor
|
FTO inhibitor FB23 is a potent and selective FTO demethylase inhibitor with IC50 of 60 nM, directly binds to FTO and selectively inhibits FTO's mRNA N6-methyladenosine (m6A) demethylase activity. |
| PC-22677 |
DDO-2728
ALKBH5 inhibitor
|
DDO-2728 is a selectiv, 2-OG independent inhibitor of mRNA m6A demethylase AlkB homologue 5 (ALKBH5) with IC50 of 2.97 uM in FP assays, does not inhibit FTO (ALKBH9) and ALKBH3. |
| PC-22581 |
TACH101 L-lysine
KDM4 inhibitor
|
TACH101 (Zavondemstat, QC8222, TACH 101) L-lysine is a reversible, α-ketoglutarate competitive, selective and potent inhibitor of KDM4 isoforms A-D with IC50 values of 80 nM against all four isoforms. |
| PC-22360 |
KDM4/5 inhibitor 19a
KDM4/5 inhibitor
|
KDM4/5 inhibitor 19a is a potent, cell penetrant, dual KDM4/5-subfamily inhibitor with Ki values of 4 nM/7 nM for KDM4A/KDM5B, respectively. |
| PC-22359 |
N19-0881
KDM5B inhibitor
|
KDM5-N19 (N19-0881) is a potent, selective, αKG-competitive KDM5B inhibitor with IC50 of 2 nM. |
| PC-22358 |
TK-129
KDM5B inhibitor
|
TK-129 is a highly potent, selective, and orally efficacious KDM5B ((lysine demethylase 5B, JARID1B) inhibitor with IC50 of 44 nM in homogeneous time-resolved fluorescence assay (HTRF). |
| PC-22357 |
2,4-PDCA
2OG oxygenase inhibitor
|
2,4-PDCA (2,4 pyridine dicarboxylic acid) is a broad-spectrum inhibitor of 2OG oxygenases, including JmjC domain-containing family of histone demethylases (JHDMs), shows acceptable KDM5B inhibition in vitro, with an IC50 value of 3 uM. |
| PC-21988 |
KDOAM-25 citrate
KDM5 inhibitor
|
KDOAM-25 citrate (KDM5 inhibitor KDOAM 25) is a potent, selective KDM5 sub-family (JARID1) inhibitor with biochemical IC50 of 71/19/69/69 nM for KDM5A/B/C/D, respectively. |
