| Cat. No. |
Product Name |
Information |
| PC-22847 |
FTO inhibitor FB23
FTO inhibitor
|
FTO inhibitor FB23 is a potent and selective FTO demethylase inhibitor with IC50 of 60 nM, directly binds to FTO and selectively inhibits FTO's mRNA N6-methyladenosine (m6A) demethylase activity. |
| PC-22677 |
DDO-2728
ALKBH5 inhibitor
|
DDO-2728 is a selectiv, 2-OG independent inhibitor of mRNA m6A demethylase AlkB homologue 5 (ALKBH5) with IC50 of 2.97 uM in FP assays, does not inhibit FTO (ALKBH9) and ALKBH3. |
| PC-22581 |
TACH101 L-lysine
KDM4 inhibitor
|
TACH101 (Zavondemstat, QC8222, TACH 101) L-lysine is a reversible, α-ketoglutarate competitive, selective and potent inhibitor of KDM4 isoforms A-D with IC50 values of 80 nM against all four isoforms. |
| PC-22360 |
KDM4/5 inhibitor 19a
KDM4/5 inhibitor
|
KDM4/5 inhibitor 19a is a potent, cell penetrant, dual KDM4/5-subfamily inhibitor with Ki values of 4 nM/7 nM for KDM4A/KDM5B, respectively. |
| PC-22359 |
N19-0881
KDM5B inhibitor
|
KDM5-N19 (N19-0881) is a potent, selective, αKG-competitive KDM5B inhibitor with IC50 of 2 nM. |
| PC-22358 |
TK-129
KDM5B inhibitor
|
TK-129 is a highly potent, selective, and orally efficacious KDM5B ((lysine demethylase 5B, JARID1B) inhibitor with IC50 of 44 nM in homogeneous time-resolved fluorescence assay (HTRF). |
| PC-22357 |
2,4-PDCA
2OG oxygenase inhibitor
|
2,4-PDCA (2,4 pyridine dicarboxylic acid) is a broad-spectrum inhibitor of 2OG oxygenases, including JmjC domain-containing family of histone demethylases (JHDMs), shows acceptable KDM5B inhibition in vitro, with an IC50 value of 3 uM. |
| PC-21988 |
KDOAM-25 citrate
KDM5 inhibitor
|
KDOAM-25 citrate (KDM5 inhibitor KDOAM 25) is a potent, selective KDM5 sub-family (JARID1) inhibitor with biochemical IC50 of 71/19/69/69 nM for KDM5A/B/C/D, respectively. |
| PC-21987 |
PBIT
KDM5 inhibitor
|
PBIT is a specific small molecule inhibitor of JARID1 family of histone lysine demethylases (KDM5) with IC50 of 3 uM for JARID1B (KDM5B or PLU1), inhibits H3K4me3 demethylation in vitro and in vivo. |
| PC-21915 |
ALKBH1 inhibitor 13h
ALKBH1 inhibitor
|
ALKBH1 inhibit 13h is a potent, isoform selective, and cell-active DNA 6mA demethylase ALKBH1 inhibitor with 26 nM and 1.39 uM in FP and enzyme activity assay, respectively. |
| PC-21875 |
WS-384
LSD1 inhibitor
|
WS-384 is a specific, small-molecule inhibitor dually targeting LSD1 (IC50=338.8 nM) and the DCN1-UBC12 interaction (IC50=14.8 uM). |
| PC-21777 |
JMJD1C inhibitor 193D7
JMJD1C inhibitor
|
193D7 is a specific and oral inhibitor of histone demethylase JMJD1C with IC50 of 0.59 uM in in vitro demethylation assays, suppresses tumor growth by targeting intratumoral Treg cells. |
