| Cat. No. |
Product Name |
Information |
| PC-42148 |
CPI-455
KDM5 inhibitor
|
CPI-455 is a potent, specific histone demethylase pan-KDM5 inhibitor with biochemical IC50 of 10, 3 and 14 nM for KDM5A, KDM5B and KDM5C, respectively. |
| PC-45495 |
GSK2879552
LSD1 inhibitor
|
GSK2879552 is a potent, selective irreversible inhibitor of LSD1 with Ki app of 1.7 uM. |
| PC-42149 |
KDM5-IN-48
KDM5 inhibitor
|
KDM5-IN-48 is a potent, selective and orally bioavailable KDM5 inhibitor with biochemical IC50 of 15.1, 4.7 and 65.5 nM for KDM5A, KDM5B and KDM5C, respectively. |
| PC-42195 |
D-alpha-Hydroxyglutaric acid disodium
Dioxygenase inhibitor
|
D-alpha-Hydroxyglutaric acid disodium (D-2-HG, D-2-hydroxyglutarate) is a competitive inhibitor of multiple α-KG-dependent dioxygenases, including histone demethylases and the TET family of 5-methlycytosine (5mC) hydroxylases. |
| PC-26560 |
KDM5-C49 hydrochloride
KDM5 inhibitor
|
KDM5-C49 hydrochloride is a potent, selective KDM5 inhibitor with IC50 of 25, 30 and 59 nM for KDM5A, B and C, respectively. |
| PC-26540 |
GSK-LSD1
LSD1 inhibitor
|
GSK-LSD1 dihydrochloride is a potent, selective and irreversible lysine specific demethylase 1 (LSD1, KDM1) inhibitor with IC50 of 16 nM. |
| PC-26539 |
MC4455
LSD1/PRMT5 inhibitor
|
MC4455 is a potent, selective dual LSD1/PRMT5 hybrid inhibitor with IC50 of 104/14 nM for LSD1/CoREST and PRMT5/MEP50, respectively. |
| PC-26437 |
DC551040 dihydrochloride
LSD1 inhibitor
|
DC551040 dihydrochloride is a potent, selective, irreversible and orally bioavailable LSD1 inhibitor with IC50 of 2.14 nM. |
| PC-26436 |
DC551040
LSD1 inhibitor
|
DC551040 is a potent, selective, irreversible and orally bioavailable LSD1 inhibitor with IC50 of 2.14 nM. |
| PC-26423 |
TAS1440
LSD1 inhibitor
|
TAS1440 (TAS-1440) is a potent, selectve, histone H3-competitive non-covalent LSD1 inhibitor with IC50 of 4.8 nM, disrupts INSM1-LSD1 complex activating tumor-suppressive pathways. |
| PC-25883 |
JMJD6 inhibitor 7p
JMJD6 inhibitor
|
JMJD6 inhibitor 7p is potent, selective JMJD6 inhibitor with IC50 of 681 nM, shows no activity against other JmjC domain-containing protein family members. |
| PC-25582 |
Methylstat
JHDMs inhibitor
|
Methylstat is a selective inhibitor of Jumonji C domain-containing histone demethylases (JHDMs) in cells, preferentially inhibits JMJD2A (H3K9me3 and H3K36me3 demethylase), JMJD2E (H3K9me3 demethylase) and JMJD3 (H3K27me3 demethylase). |
