| Cat. No. |
Product Name |
Information |
| PC-42028 |
KDM5A-IN-1
KDM5 inhibitor
|
KDM5A-IN-1 is a potent, orally bioavailable histone lysine demethylases 5 (KDM5) inhibitor with IC50 of 45 nM, 56 nM and 55 nM for KDM5A, KDM5B and KDM5C, respectively. |
| PC-42148 |
CPI-455
KDM5 inhibitor
|
CPI-455 is a potent, specific histone demethylase pan-KDM5 inhibitor with biochemical IC50 of 10, 3 and 14 nM for KDM5A, KDM5B and KDM5C, respectively. |
| PC-45495 |
GSK2879552
LSD1 inhibitor
|
GSK2879552 is a potent, selective irreversible inhibitor of LSD1 with Ki app of 1.7 uM. |
| PC-42149 |
KDM5-IN-48
KDM5 inhibitor
|
KDM5-IN-48 is a potent, selective and orally bioavailable KDM5 inhibitor with biochemical IC50 of 15.1, 4.7 and 65.5 nM for KDM5A, KDM5B and KDM5C, respectively. |
| PC-42195 |
D-alpha-Hydroxyglutaric acid disodium
Dioxygenase inhibitor
|
D-alpha-Hydroxyglutaric acid disodium (D-2-HG, D-2-hydroxyglutarate) is a competitive inhibitor of multiple α-KG-dependent dioxygenases, including histone demethylases and the TET family of 5-methlycytosine (5mC) hydroxylases. |
| PC-26949 |
NCGC00247743
KDM4 inhibitor
|
NCGC00247743 is a selective inhibitor of histone lysine demethylase KDM4/JMJD2s with IC50 of 10 nM for KDM4B, inhibits LNCaP cell growth with IC50 in the μM range, shows no or weak activity for KDM5A/JARID1A. |
| PC-26937 |
NCGC00244536
KDM4B inhibitor
|
NCGC00244536 (B3) is a potent, speciifc lysine demethylase 4B (KDM4B, JMJD2B) inhibitor with an IC50 of 10 nM, inhibits LNCaP cell growth with IC50s in the μM range, shows no or weak activity for KDM5A/JARID1A. |
| PC-26560 |
KDM5-C49 hydrochloride
KDM5 inhibitor
|
KDM5-C49 hydrochloride is a potent, selective KDM5 inhibitor with IC50 of 25, 30 and 59 nM for KDM5A, B and C, respectively. |
| PC-26540 |
GSK-LSD1
LSD1 inhibitor
|
GSK-LSD1 dihydrochloride is a potent, selective and irreversible lysine specific demethylase 1 (LSD1, KDM1) inhibitor with IC50 of 16 nM. |
| PC-26539 |
MC4455
LSD1/PRMT5 inhibitor
|
MC4455 is a potent, selective dual LSD1/PRMT5 hybrid inhibitor with IC50 of 104/14 nM for LSD1/CoREST and PRMT5/MEP50, respectively. |
| PC-26437 |
DC551040 dihydrochloride
LSD1 inhibitor
|
DC551040 dihydrochloride is a potent, selective, irreversible and orally bioavailable LSD1 inhibitor with IC50 of 2.14 nM. |
| PC-26423 |
TAS1440
LSD1 inhibitor
|
TAS1440 (TAS-1440) is a potent, selectve, histone H3-competitive non-covalent LSD1 inhibitor with IC50 of 4.8 nM, disrupts INSM1-LSD1 complex activating tumor-suppressive pathways. |
