| Cat. No. |
Product Name |
Information |
| PC-22359 |
N19-0881
KDM5B inhibitor
|
KDM5-N19 (N19-0881) is a potent, selective, αKG-competitive KDM5B inhibitor with IC50 of 2 nM. |
| PC-22358 |
TK-129
KDM5B inhibitor
|
TK-129 is a highly potent, selective, and orally efficacious KDM5B ((lysine demethylase 5B, JARID1B) inhibitor with IC50 of 44 nM in homogeneous time-resolved fluorescence assay (HTRF). |
| PC-22357 |
2,4-PDCA
2OG oxygenase inhibitor
|
2,4-PDCA (2,4 pyridine dicarboxylic acid) is a broad-spectrum inhibitor of 2OG oxygenases, including JmjC domain-containing family of histone demethylases (JHDMs), shows acceptable KDM5B inhibition in vitro, with an IC50 value of 3 uM. |
| PC-21988 |
KDOAM-25 citrate
KDM5 inhibitor
|
KDOAM-25 citrate (KDM5 inhibitor KDOAM 25) is a potent, selective KDM5 sub-family (JARID1) inhibitor with biochemical IC50 of 71/19/69/69 nM for KDM5A/B/C/D, respectively. |
| PC-21987 |
PBIT
KDM5 inhibitor
|
PBIT is a specific small molecule inhibitor of JARID1 family of histone lysine demethylases (KDM5) with IC50 of 3 uM for JARID1B (KDM5B or PLU1), inhibits H3K4me3 demethylation in vitro and in vivo. |
| PC-21915 |
ALKBH1 inhibitor 13h
ALKBH1 inhibitor
|
ALKBH1 inhibit 13h is a potent, isoform selective, and cell-active DNA 6mA demethylase ALKBH1 inhibitor with 26 nM and 1.39 uM in FP and enzyme activity assay, respectively. |
| PC-21875 |
WS-384
LSD1 inhibitor
|
WS-384 is a specific, small-molecule inhibitor dually targeting LSD1 (IC50=338.8 nM) and the DCN1-UBC12 interaction (IC50=14.8 uM). |
| PC-21777 |
JMJD1C inhibitor 193D7
JMJD1C inhibitor
|
193D7 is a specific and oral inhibitor of histone demethylase JMJD1C with IC50 of 0.59 uM in in vitro demethylation assays, suppresses tumor growth by targeting intratumoral Treg cells. |
| PC-21684 |
iPHF8
PHF8 inhibitor
|
iPHF8 (inhibitor of PHF8) is a specific inhibitor of protein demethylase PHF8 with IC50 of 2.01 uM in Succinate-Glo JmjC demethylase assays, and SPR KD value of 240 nM. |
| PC-21211 |
GSK-J4
KDM6A/6B inhibitor
|
GSK-J4 is a potent dual inhibitor of H3K27me3/me2-demethylases JMJD3/KDM6B and UTX/KDM6A with IC50s of 8.6 and 6.6 μM, respectively, GSK-J4 s a cell permeable prodrug of GSK-J1. |
| PC-20876 |
ZY0511
LSD1 inhibitor
|
ZY0511 is a highly selective and potent inhibitor of lysine‐specific histone demethylase 1 (LSD1) with IC50 of 1.7 nM and SPR Kd of 2.42 nM. |
| PC-20519 |
TAK-418
LSD1 (KDM1A) inhibitor
|
TAK-418 (TAK418) is a potent, specific inhibitor of LSD1 (KDM1A) enzyme activity with IC50 of 2.9 nM. |
