| Cat. No. |
Product Name |
Information |
| PC-20826 |
TX-1918
HIV-1 capsid inhibitor, eEF-2K inhibitor
|
TX-1918 (TX1918) is a specific inhibitor of HIV-1 capsid assembly taregting the C-terminal domain of HIV-1 capsid (CA CTD) with IC50 of 3.81 uM, inhibits viral replication (EC50=15.16 μM) and inhibits CA assembly in vitro. |
| PC-20164 |
iPAF1C
PAF1C inhibitor
|
iPAF1C (PAF1C inhibitor) is a first-in-class, specific inhibitor of polymerase-associated factor 1 complex (PAF1C), iPAF1C binds specifically to CTR9 and disrupts of PAF1-CTR9 interaction, enhances HIV-1 latency reversal. |
| PC-20150 |
TACK molecule Pyr01
HIV-1 Gag-Pol inhibitor
|
TACK molecule Pyr01 is a potent targeted activator of cell kill (TACK) small molecule, binds to HIV-1 reverse transcriptase-p66 domain of monomeric Gag-Pol. |
| PC-49723 |
GSK878
HIV-1 Capsid inhibitor
|
GSK-878 (GSK878) is a highly potent, long-acting inhibitor targeting the HIV-1 capsid with picomolar potency against HIV-1 infection in vitro (EC50=39 pM). |
| PC-49592 |
YIR-819
CD4 mimic
|
YIR-819 is a small-molecule CD4 mimic that acts as a highly potent HIV entry inhibitor with IC50 of 2.6 uM against YTA48P virus with no significant cytotoxicity (CC50=33 uM). |
| PC-49515 |
GSK1264
HIV-1 integrase inhibitor
|
GSK1264 is an allosteric inhibitor of HIV-1 integrase, disrupts the interaction between HIV-1 integrase (IN) and the cellular factor LEDGF/p75 with IC50 of 8.2 nM, inhibits HIV-1 replication with IC50 of 38 nM. |
| PC-49168 |
PAV-206
HIV-1 inhibitor
|
PAV-206 is a novel potent antiretroviral chemotype that inhibits HIV-1 replication with EC50 of 34 nM in HIV-1-infected MT-2 T cells, and 75 nM in HIV-1-infected peripheral blood mononuclear cells (PBMCs), inhibits HIV-1 replication by interfering with HIV-1 assembly. |
| PC-49139 |
RO-0335
NNRTI
|
RO-0335 is a highly potent, selective nonnucleoside reverse transcriptase inhibitor (NNRTI) of HIV-1 with IC50 of 8.1 nM, potently inhibits HIV replication with IC50 of 1.3 nM in cell based assays. |
| PC-47033 |
VTD227
HIV-1 Vpr inhibitor
|
VTD227 is a small molecule Vpr-targeting HIV-1 inhibitor, directly binds to Vpr with Kd of 8.8 uM, inhibits HIV-1 replication in monocyte-derived macrophages (MDM) with IC50 of 0.78 uM. |
| PC-38861 |
SO-7g
NNRTI
|
SO-7g is a novel highly active HIV-1 nonnucleoside reverse transcriptase inhibitor (NNRTI), exhibits moderate to excellent potency against wild-type HIV-1 with EC50 of 5.3 nM. |
| PC-38563 |
Temsavir
HIV-1 attachment inhibitor
|
Temsavir (BMS-626529) is a highly potent, small molecule HIV-1 attachment inhibitor with IC50 values of 2.26 nM, 0.34 nM and 1.3 nM for HIV-1 subtype A, B, and C envelope, repectively. |
| PC-38555 |
ACAi-028
HIV-1 capsid inhibitor
|
ACAi-028 is a small molecule inhibiting HIV-1 replication (EC50=0.55 uM) that targets a hydrophobic pocket in the N-terminal domain of capsid (CA-NTD). |
