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Chemical Structure : TX-1918
Catalog No.: PC-20826Not For Human Use, Lab Use Only.
TX-1918 (TX1918) is a specific inhibitor of HIV-1 capsid assembly taregting the C-terminal domain of HIV-1 capsid (CA CTD) with IC50 of 3.81 uM, inhibits viral replication (EC50=15.16 μM) and inhibits CA assembly in vitro.
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TX-1918 (TX1918) is a specific inhibitor of HIV-1 capsid assembly taregting the C-terminal domain of HIV-1 capsid (CA CTD) with IC50 of 3.81 uM, inhibits viral replication (EC50=15.16 μM) and inhibits CA assembly in vitro.
TX-1918 has an antiviral EC50 of 6.57 μM and cellular cytotoxicity CC50 of 102.55 μM was obtained from a compound similarity search.
TX-1918 also is an eEF-2K inhibitor, inhibits many kinases including Src, PKA, PKC, and EGFR.
| M.Wt | 228.25 | |
| Formula | C14H12O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Da-Wei Zhang, et al. Antiviral Res. 2019 Sep;169:104544.
2. Hori H.et al. Bioorg. Med. Chem. 10, 3257–3265. 10.1016/S0968-0896(02)00160-8.
3. Devkota A. K.et al. ChemBioChem 15, 2435–42. 10.1002/cbic.201402321.
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