| Cat. No. |
Product Name |
Information |
| PC-24977 |
Icotrokinra
IL-23 receptor antagonist
|
Icotrokinra (JNJ-77242113, PN-21235) is a highly potent, selective peptide antagonist targeting the IL-23 receptor with KD of 7.1 pM, potently and selectively inhibits proximal IL-23 signaling (IC50=5.6 pM) without impacting IL-12 signaling. |
| PC-20616 |
Bindarit
MCP-1 inhibitor
|
Bindarit (AF2838) is a selective inhibition of inflammatory chemokine MCP-1/CCL2, MCP-3/CCL7, and MCP-2/CCL8, shows immunosuppressive effects anti-inflammatory activity. |
| PC-20490 |
R805
gp130 modulator
|
R805 is a small molecule modulator of gp130 receptor pro-inflammatory signaling, targets a signaling tyrosine 814 (Y814) within gp130, modulates gp130 Y814 upstream of the SRC and MAPK circuit, elicits a protective effect on tissues after injury. |
| PC-20420 |
SC144
gp130 inhibitor
|
SC144 (SC-144) is the first-in-class orally active small-molecule gp130 (IL-6Rβ) inhibitor with a broad-spectrum anticancer activity. |
| PC-49391 |
Rytvela
IL-1RI inhibitor
|
Rytvela (Peptide 101.10, d-(RYTVELA)) is a potent, selective, allosteric negative modulator (antagonist) of IL-1 receptor I (IL-1RI), inhibits dose-dependently IL-1-induced PGE2 formation (IC50= 0.5 nM) and IL-1-induced human thymocyte (TF-1 cell) proliferation (IC50=2 nM). |
| PC-72919 |
A-552
L-36γ antagonist
|
A-552 (A552) is a potent, small molecule antagonist of human IL-36γ, exhibits Ki of 31/54 nM in IL-36γ evoked CXCL1 release in human/mouse cellular assays. |
| PC-72481 |
IL4 inhibitor 52
IL4 inhibitor
|
IL4 inhibitor 52 is the first IL-4 small-molecule inhibitor (EC50=1.81 uM) with potency for the cytokine and disrupts type II IL-4 signaling in cells. |
| PC-35897 |
LMT-28
IL-6 inhibitor
|
LMT-28 (LMT28) is a specific blocker of IL-6 signaling via inhibits IL-6Rβ (gp130) with IC50 of 5.9 uM (IL-6–induced luciferase activity), selectively inhibits IL-6–induced phosphorylation of STAT3, JAK2, and gp130. |
| PC-63195 |
RCGD423
gp130 modulator
|
RCGD423 (RCGD-423) is a small molecule gp130 modulator that prevents articular cartilage degeneration and promotes repair both in vitro and in vivo. |
| PC-62479 |
SP4206
IL-2α receptor inhibitor
|
SP4206 is a high-affinity (Kd=70 nM) small molecule that blocks the binding of the IL-2α receptor (IL-2Rα) to IL-2. |
| PC-45128 |
Suplatast tosilate
Th2 cytokine inhibitor
|
Suplatast tosilate (IPD-1151T) is a Th2 cytokine inhibitor that attenuates IL-2, IL-5 and IL-13 production and has no effect on IFN-γ production. |
| PC-45769 |
YM-90709
IL-5 receptor inhibitor
|
YM-90709 (YM90709) is a potent IL-5 receptor antagonist that inhibits the binding of IL-5 to its receptor on peripheral human eosinophils and butyric acid-treated eosinophilic HL-60 clone 15 cells with IC50 of 1.0 and 0.57 uM, respectively. |
