| Cat. No. |
Product Name |
Information |
| PC-25093 |
Simepdekinra
IL-17A modulator
|
Simepdekinra is a potent, selective modulator of interleukin 17A (IL-17A). |
| PC-24977 |
Icotrokinra
IL-23 receptor antagonist
|
Icotrokinra (JNJ-77242113, PN-21235) is a highly potent, selective peptide antagonist targeting the IL-23 receptor with KD of 7.1 pM, potently and selectively inhibits proximal IL-23 signaling (IC50=5.6 pM) without impacting IL-12 signaling. |
| PC-24963 |
Navepdekinra
IL-17A inhibitor
|
Navepdekinra (DC-806, S 011806, LY4100504) is a potent, oral, next-generation interleukin-17A (IL-17A) inhibitor. |
| PC-21800 |
LY3509754
IL-17A inhibitor
|
LY3509754 is a potent, selective and oral small molecule inhibitor of IL-17A with high binding potency(KD=2.14 nM), dose-dependently prevents human IL-17A and IL-17AF from binding human IL-17RA. |
| PC-20616 |
Bindarit
MCP-1 inhibitor
|
Bindarit (AF2838) is a selective inhibition of inflammatory chemokine MCP-1/CCL2, MCP-3/CCL7, and MCP-2/CCL8, shows immunosuppressive effects anti-inflammatory activity. |
| PC-20490 |
R805
gp130 modulator
|
R805 is a small molecule modulator of gp130 receptor pro-inflammatory signaling, targets a signaling tyrosine 814 (Y814) within gp130, modulates gp130 Y814 upstream of the SRC and MAPK circuit, elicits a protective effect on tissues after injury. |
| PC-20420 |
SC144
gp130 inhibitor
|
SC144 (SC-144) is the first-in-class orally active small-molecule gp130 (IL-6Rβ) inhibitor with a broad-spectrum anticancer activity. |
| PC-49391 |
Rytvela
IL-1RI inhibitor
|
Rytvela (Peptide 101.10, d-(RYTVELA)) is a potent, selective, allosteric negative modulator (antagonist) of IL-1 receptor I (IL-1RI), inhibits dose-dependently IL-1-induced PGE2 formation (IC50= 0.5 nM) and IL-1-induced human thymocyte (TF-1 cell) proliferation (IC50=2 nM). |
| PC-47087 |
IL-17A PPIm 23
IL-17A modulator
|
IL-17A PPIm 23 is a potent, orally bioavailable, small-molecule protein-protein interaction modulator (PPIm) of IL-17A, shows potential treatment of psoriasis and other inflammatory diseases. |
| PC-72919 |
A-552
L-36γ antagonist
|
A-552 (A552) is a potent, small molecule antagonist of human IL-36γ, exhibits Ki of 31/54 nM in IL-36γ evoked CXCL1 release in human/mouse cellular assays. |
| PC-72901 |
LP0200
IL17 modulator
|
LP0200 (IL-17 modulator 1 disodium, LP-0200) is a small-molecule modulator of IL-17 under development for psoriasis. |
| PC-72481 |
IL4 inhibitor 52
IL4 inhibitor
|
IL4 inhibitor 52 is the first IL-4 small-molecule inhibitor (EC50=1.81 uM) with potency for the cytokine and disrupts type II IL-4 signaling in cells. |
