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SP4206

Chemical Structure : SP4206

CAS No.: 515846-21-6

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SP4206 (SP-4206)

Catalog No.: PC-62479Not For Human Use, Lab Use Only.

SP4206 is a high-affinity (Kd=70 nM) small molecule that blocks the binding of the IL-2α receptor (IL-2Rα) to IL-2.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    SP4206 is a high-affinity (Kd=70 nM) small molecule that blocks the binding of the IL-2α receptor (IL-2Rα) to IL-2.
    SP4206 targets virtually the same critical "hot-spot" residues on IL-2 that drive binding of IL-2Rα.

    Physicochemical Properties

    M.Wt 662.57
    Formula C30H37Cl2N7O6
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    5-[[2,3-dichloro-4-[5-[1-[2-[[(2R)-2-(diaminomethylideneamino)-4-methylpentanoyl]amino]acetyl]piperidin-4-yl]-1-methylpyrazol-3-yl]phenoxy]methyl]furan-2-carboxylic acid

    References

    1. Arkin MR, et al. Chem Biol. 2014 Sep 18;21(9):1102-14.

    2. Thanos CD, et al. Proc Natl Acad Sci U S A. 2006 Oct 17;103(42):15422-7.

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